PMID: 8591646Nov 1, 1995Paper

Anti-cytokine therapy in rheumatoid arthritis

Baillière's Clinical Rheumatology
M J Elliott, R N Maini

Abstract

The past few years have seen an explosion of knowledge concerning the role of cytokines and their naturally occurring inhibitors in the promotion and modulation of inflammatory disease. In RA, this knowledge has been translated into the clinic, with ongoing evaluation of specific cytokine inhibitors, including those targeting tumour necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1) and interleukin-6 (IL-6). In this review, we outline the scientific data supporting anti-cytokine therapies in RA and describe the results of published and unpublished clinical trials with biological agents. At least for anti-TNF therapy, short-term clinical efficacy and good tolerability have been confirmed in randomized, placebo controlled trials. The results of IL-1 blockade in vivo also appear encouraging, although detailed descriptions of trail outcomes are awaited. Problems associated with long-term administration of biological agents are discussed, including the development of antiglobulin responses to injected monoclonal antibodies and poor pharmacokinetics of low-molecular-weight inhibitors. Ways of facilitating the long-term use of current biological agents and alternative means for inhibiting cytokine function in future studies in RA...Continue Reading

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Citations

Oct 16, 2001·Journal of Pharmaceutical and Biomedical Analysis·T SchenkJ van der Greef
Apr 1, 1997·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·R N MainiM Feldmann
Dec 21, 2013·British Journal of Clinical Pharmacology·David TernantDenis Mulleman
Mar 10, 2009·Journal of Pharmacological Sciences·Yukari NakamuraYukio Yoneda
Mar 14, 2002·Critical Reviews in Clinical Laboratory Sciences·Leonardo PunziMario Plebani
Jan 10, 2006·Periodontology 2000·Alpdogan KantarciThomas E Van Dyke
Jun 1, 1997·Obstetrical & Gynecological Survey·I P Ryan, R N Taylor
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Jul 11, 2003·Ocular Immunology and Inflammation·Andrew D Dick, Debra A Carter
May 29, 2018·Clinical Pharmacokinetics·David TernantGilles Paintaud

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