Abstract
Recent studies have implicated human cytomegalovirus (HCMV) infection as a possible etiological factor in cardiovascular disease. We assessed whether anti-HCMV antibody levels are associated with carotid atherosclerosis and inflammatory cytokine production in elderly Koreans. Participants (age, ≥65 years) were prospectively enrolled from September 2012 to July 2013 at a 2000-bed university hospital. During the study period, 71 participants (29 males) were prospectively enrolled, and thirty-five (49.3%) of these individuals were in the group designated as high intima-media thickness (IMT). Multivariate logistic regression analysis revealed three independent risk factors of high IMT: higher levels of anti-HCMV antibody (odds ratio [OR] 1.04, p=0.003), Framingham score (OR 1.14, p=0.018), and levels of IL-1β (OR 2.96, p=0.013). Anti-HCMV antibody levels had a significantly positive correlation with max-IMT (r=0.523, p<0.001), free T4 levels (r=0.315, p=0.021), and Log(TNF-α) (r=0.562, p<0.001) in multivariate correlation analysis. These findings may provide insight into the role of HCMV in the pathogenesis of atherosclerosis and chronic inflammation in elderly individuals.
References
Dec 1, 1986·Circulation·P PignoliR Paoletti
Jul 15, 1994·Science·E SpeirS E Epstein
Aug 29, 1996·The New England Journal of Medicine·Y F ZhouS E Epstein
Aug 9, 1997·Lancet·J DaneshR Peto
Apr 27, 1999·Circulation·L M BiasucciA Maseri
Jul 7, 1999·Circulation·H A ValantineJ S Schroeder
Mar 25, 2000·The New England Journal of Medicine·P M RidkerN Rifai
Jul 19, 2000·Circulation·P J TouboulP Amarenco
May 23, 2001·Atherosclerosis·E HsichS E Epstein
Jul 4, 2001·Circulation·H J RupprechtUNKNOWN AutoGene Investigators
Aug 30, 2002·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·M InabaY Nishizawa
Nov 2, 2002·Stroke; a Journal of Cerebral Circulation·Christine Espinola-KleinJürgen Meyer
Aug 6, 2003·Circulation·Cairistine Grahame-ClarkePatrick Vallance
Jun 12, 2004·European Journal of Endocrinology·E A PalmieriB Biondi
Aug 2, 2005·Thyroid : Official Journal of the American Thyroid Association·Moffat J NyirendaAnthony D Toft
Jan 3, 2006·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Frank R StassenCathrien A Bruggeman
Jun 6, 2006·Cytokine & Growth Factor Reviews·Dimitris TousoulisChristodoulos Stefanadis
Nov 23, 2006·AIDS·Priscilla Y HsueSteven G Deeks
May 2, 2008·Journal of Virology·Jerome DumortierJay A Nelson
May 14, 2009·PLoS Pathogens·Jilin ChengClyde S Crumpacker
Jan 16, 2010·Stroke; a Journal of Cerebral Circulation·Mitchell S V ElkindMyunghee C Paik
Jan 20, 2011·Current Opinion in Nephrology and Hypertension·Dominik N MullerFriedrich C Luft
Feb 22, 2011·Trends in Immunology·Frank L van de VeerdonkLeo A B Joosten
Apr 28, 2011·European Journal of Immunology·Charles A Dinarello
Jun 22, 2011·Circulation·Shuqiang LiJun Cai
Jan 13, 2012·Clinical and Experimental Immunology·A HaaralaM Hurme
Apr 24, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Monisha Banerjee, Madhukar Saxena
Aug 2, 2012·Nature Reviews. Drug Discovery·Charles A DinarelloJos W M van der Meer
Citations
Feb 18, 2016·Age·Midori KawasakiNobuyoshi Hirose
Feb 8, 2018·Virology Journal·Yu DuZhijun Liu
Aug 25, 2017·PloS One·Zhen LiFang He
Sep 14, 2017·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·N GuoH Cong
Apr 8, 2020·Acta Biochimica Et Biophysica Sinica·Wenbo Zhu, Shuangquan Liu
May 30, 2020·The Journal of Gene Medicine·Dan LiJiawei Wang
Mar 18, 2019·Biochemistry. Biokhimii︠a︡·A M LebedevaL B Margolis
Dec 19, 2016·BioMed Research International·Zhe WangXinchun Yang
Oct 30, 2020·Risk Management and Healthcare Policy·Zhi-Xin HuangZhenguo Liu
Feb 26, 2021·Journal of Medical Virology·Agnieszka JabłońskaIhor Huk