Anti-D administration in pregnancy for preventing Rhesus alloimmunisation

The Cochrane Database of Systematic Reviews
Rosemary D McBainP Middleton

Abstract

During pregnancy, a Rhesus negative (Rh-negative) woman may develop antibodies when her fetus is Rhesus positive (Rh-positive). These antibodies may harm Rh-positive babies. To assess the effects of antenatal anti-D immunoglobulin on the incidence of Rhesus D alloimmunisation when given to Rh-negative women without anti-D antibodies. We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (31 May 2015) and reference lists of retrieved studies. Randomised trials in Rh-negative women without anti-D antibodies given anti-D after 28 weeks of pregnancy, compared with no treatment, placebo or a different regimen of anti-D. Two review authors independently assessed trials for inclusion and risk of bias, extracted data and checked them for accuracy. We included two trials involving over 4500 women, comparing anti-D prophylaxis with no anti-D during pregnancy in this review. Overall, the trials were judged to be at moderate to high risk of bias. The quality of the evidence for pre-specified outcomes was also assessed using the GRADE (Grades of Recommendation, Assessment, Development and Evaluation) approach.In regards to primary review outcomes, there did not appear to be a clear difference in the risks of immunisation...Continue Reading

References

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Citations

Nov 17, 2017·BMC Public Health·Hannah BlencoweZulfiqar A Bhutta
Jun 4, 2020·Obstetrics & Gynecology Science·Rahul Vishwanath MayekarGanesh Harishchandra Divekar
Dec 24, 2018·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Beate MayerAbdulgabar Salama
Jul 26, 2017·Obstetrics and Gynecology·UNKNOWN Committee on Practice Bulletins-Obstetrics
Feb 9, 2020·BMC Pregnancy and Childbirth·Britta RunkelDaniel Fleer

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