Anti-depressant action of caesium chloride and its modification of chlorpromazine toxicity in mice

British Journal of Pharmacology
F S Messiha

Abstract

1. Adult male mice were treated with caesium chloride (1.0 mEq/kg, i.p.) once daily for 54 consecutive days before administration of a single dose or reserpine (2.0 mg/kg) or (+)-amphetamine (1.0 mg/kg). Pretreatment with caesium chloride resulted in potentiation of amphetamine-produced enhancement of motility and in antagonism of reserpine-induced behavioural depression in mice as measured by a locomotor activity test, compared to the respective controls. 2. Chronic administration of caesium chloride (1.0 mEq/kg daily) with gradual dose build-up of chlorpromazine (up to 50 mg kg-1 day-1) counteracted chlorpromazine-produced mortality in mice. 3. The results suggest an antidepressant property of Cs+ and the combined treatment of caesium chloride with chlorpromazine might have a clinical application, i.e. in the management of chlorpromazine-induced adverse reaction.

References

Nov 1, 1975·The Journal of Pharmacy and Pharmacology·F S Messina
Jan 1, 1976·Pharmacology·F S Messiha
Jan 1, 1973·The American Journal of Psychiatry·R R FieveA Thomas
Sep 1, 1966·Life Sciences·D J George, H H Wolf

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Citations

Jan 1, 1984·Psychopharmacology·R Bose, C Pinsky
Aug 1, 1993·Biological Trace Element Research·A GhoshG Talukder
Nov 1, 1978·Pharmacology, Biochemistry, and Behavior·F S Messiha
Jan 1, 1984·Pharmacology, Biochemistry, and Behavior·F S Messiha
Jan 1, 1984·Pharmacology, Biochemistry, and Behavior·F S Messiha
Sep 1, 1985·Journal of Affective Disorders·S A AliN I Ward
Aug 1, 1983·Brain Research Bulletin·H F Sproat, F S Messiha
Jan 1, 1988·Neuroscience and Biobehavioral Reviews·F S Messiha
Jan 1, 1988·Neuroscience and Biobehavioral Reviews·F S Messiha

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