Anti-depressant effects of Xiaoyaosan on rat model of chronic unpredictable mild stress: a plasma metabonomics study based on NMR spectroscopy

The Journal of Pharmacy and Pharmacology
Xiao-Jie LiuXue-Mei Qin

Abstract

To investigate the antidepressant effects of Xiaoyaosan (XYS) in a chronic unpredictable mild stress (CUMS) depression model. The changes in behaviour and plasma metabolic profiles were investigated after four-week CUMS exposure and treatment. Drugs were administered during the four-week period of CUMS, with the healthy group serving as negative controls, and the fluoxetine and venlafaxine groups serving as positive controls. Plasma samples were collected at 28th day, and the plasma metabolic profiling was measured using NMR, followed by multivariate analysis. Exposure to CUMS for four weeks caused depression-like behaviour in rats, as indicated by significant decreases in weight gain, sucrose consumption and locomotor activity. Eleven potential biomarkers, including seven in the Carr-Purcell-Meiboom-Gill spectra, five in the diffusion-edited spectra, and one in both were identified. It was found that trimethylamine-N-oxide, alanine, β-hydroxybutyrate, valine, leucine/isoleucine, low-density lipoprotein/very low-density lipoprotein and lipids were lower and phosphatidylcholine, high-density lipoprotein, choline and N-acetyl glycoproteins were higher in CUMS-treated rats, as compared with controls. XYS significantly suppressed b...Continue Reading

References

Dec 1, 1971·The American Journal of Physiology·W H Oldendorf
Jan 1, 1997·Journal of Analytical Toxicology·R L Fitzgerald, D A Herold
Feb 1, 1997·Biochemical Society Transactions·H C HolmesR A Iles
Mar 13, 1998·Gastroenterology·Q Aziz, D G Thompson
Jun 17, 1998·The Journal of Clinical Endocrinology and Metabolism·Z A ErkutD F Swaab
Jun 17, 1998·Endocrine Reviews·E R De KloetM Joëls
Oct 21, 1998·Developmental Neuroscience·Y Daikhin, M Yudkoff
Jul 19, 2000·Journal of Neurochemistry·H S WaagepetersenA Schousboe
Mar 29, 2001·Biological Psychiatry·C M Pariante, A H Miller
Aug 9, 2003·Nature Reviews. Drug Discovery·Jeremy K Nicholson, Ian D Wilson
Nov 18, 2003·Chemical Research in Toxicology·Andrew W NichollsJeremy K Nicholson
Jun 19, 2004·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·John C LindonJeremy K Nicholson
Jul 1, 2004·The Journal of Biological Chemistry·Francesca MagnaniJana Haase
Jul 21, 2004·Psychiatry Research·Alessandro SerrettiEnrico Smeraldi
Jul 16, 2005·Stress : the International Journal on the Biology of Stress·Carmine M Pariante
Dec 21, 2005·The Journal of Nutrition·Yoshiharu Shimomura, Robert A Harris
Jan 21, 2006·The Journal of Nutrition·Eva Blomstrand
Oct 19, 2006·International Journal of Geriatric Psychiatry·Lisa A PaigeDavid C Steffens
Jan 5, 2007·World Journal of Gastroenterology : WJG·Nimzing-G LadepAbraham-O Malu
Feb 3, 2007·Journal of Proteome Research·Johan TryggTorbjörn Lundstedt
Feb 15, 2007·The FEBS Journal·John C LindonJeremy K Nicholson
Apr 12, 2008·Neuropharmacology·Zeljka Korade, Anne K Kenworthy
Nov 18, 2008·European Journal of Pharmacology·Tatsuro MurakamiMitsuhiro Furuse
Mar 19, 2009·Journal of Proteome Research·Xiaoyan WangWei Jia
Jun 2, 2009·Behavioural Brain Research·Takahiro YaguchiTomoyuki Nishizaki

❮ Previous
Next ❯

Citations

May 3, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Haiying DongXiaojie Zhang
Jul 21, 2015·Chinese Medicine·Lin-Lin JingXue-Gang Sun
May 17, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ahmed M MetwalyDou Deqiang
Sep 10, 2014·Molecular BioSystems·Zhen-Yu LiGuan-Hua Du
Feb 11, 2015·World Journal of Gastroenterology : WJG·Ping LiHui-Shu Guo
Jul 14, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Lina LiuFei Qiao
Dec 14, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Yu GuoWei Wei
Dec 12, 2018·International Immunopharmacology·Jiucui TongLiuwang Nie
Jun 7, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Xiaojie LiuXuemei Qin
Jul 6, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xinyi GuMingmei Zhou

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.