Anti-diabetic activity of SMK001, a poly herbal formula in streptozotocin induced diabetic rats: therapeutic study

Biological & Pharmaceutical Bulletin
Jong-Dae KimSae-Kwang Ku

Abstract

The therapeutic anti-diabetic effect of SMK001, a poly herbal formula was evaluated in the streptozotocin (STZ; 60 mg/kg, single intraperitoneal injection) induced diabetic rats. For therapeutic study, test articles were orally dosed once a day from 21 d after STZ-dosing at 100, 200 and 500 mg/kg/5 ml dosage levels for 4 weeks. The body weight changes, blood and urine glucose level changes were monitored with changes on the pancreas weight, and after sacrifice, the histopathological changes of pancreas and the changes of insulin- and glucagon-producing cells were also observed by immunohistochemistry. The results were compared to that of glibenclamide 5 mg/kg-dosing group. Significantly (p<0.01 or p<0.05) decrease of body weight, blood and urine glucose levels were detected in STZ-induced diabetic animals with disruption and disappearance of pancreatic islets. In addition, significantly (p<0.01) increase of glucagon- and decrease of insulin-producing cells were detected in STZ induced diabetic rats. However, these diabetic changes were significantly (p<0.01 or p<0.05) and dose dependently decreased in SMK001-dosing groups, and SMK001 100 mg/kg showed more favorable effects compared to that of glibenclamide 5 mg/kg. Based on the...Continue Reading

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Citations

Feb 22, 2012·Indian Journal of Pharmacology·Hyo Won JungYong-Ki Park
Jun 26, 2007·Bioscience, Biotechnology, and Biochemistry·Jong-Dae KimSae-Kwang Ku
Oct 12, 2016·Archives of Oral Biology·Luciano Tavares Angelo CintraJoão Eduardo Gomes-Filho
Feb 29, 2008·The American Journal of Chinese Medicine·Xian-Kang FangDan-Ni Zhu
Oct 29, 2014·Diabetes & Metabolism Journal·Chinedum Ogbonnaya EleazuMercy Amarachi Iroaganachi
Jun 28, 2016·Experimental and Therapeutic Medicine·Sae Kwang KuJoo Wan Kim
Jul 20, 2021·Endocrinology, Diabetes & Metabolism·Tuchina Taisiia PavlovnaGalagudza Mikhail Mikhailovich

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