Anti-diabetic nephropathy compounds from Cinnamomum cassia

Journal of Ethnopharmacology
Yong-Ming YanYong-Xian Cheng

Abstract

The bark of Cinnamomum cassia, called 'Rou-Gui', a traditional spice and medicine in China, is used to treat diseases resulted from kidney yang deficiency, including diabetic nephropathy. The aim of this study is to investigate the anti-diabetic nephropathy activity of Rou-Gui and the active compounds in it. The air-dried bark of C. cassia was extracted with 90% EtOH, the obtained residue was successively partitioned by petroleum ether, EtOAc, and n-BuOH followed by concentrating to give petroleum ether (RG-1), EtOAc (RG-2), n-BuOH (RG-3), and water fraction (RG-4), respectively. The anti-diabetic nephropathy activity of fraction (RG-1-4) was evaluated in vitro by inhibiting the expression of fibronectin, monocyte chemoattractant protein-1 and interleukin-6 in high-glucose-induced mesangial cells. By bioassay screenings, repeated column chromatography on fractions of RG-1, 2, and 3, led to the isolation of 23 compounds, whose structures were determined by extensive spectroscopic analyses, and the anti-diabetic nephropathy activity of the isolated compounds was also evaluated. Four new sesquiterpenoids, cinnamoids A-D (1-4), a new natural product (5), and 18 known compounds (6-23) were isolated from the EtOH extract of the bark ...Continue Reading

References

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Citations

Jun 25, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Birgit WaltenbergerAtanas G Atanasov
May 10, 2019·PLoS Neglected Tropical Diseases·Farhat AfrinHassan A Hemeg
Dec 12, 2018·Journal of Cellular Physiology·Habib YaribeygiAmirhossein Sahebkar
Sep 29, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chunling ZhangLingying Yu
Mar 11, 2017·Natural Product Research·Jun-Fen ZengYong-Hui Zhang
Mar 9, 2021·Journal of Natural Products·Suk Woo ChangDae Sik Jang

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