Anti-diabetic properties of Momordica charantia L. polysaccharide in alloxan-induced diabetic mice

International Journal of Biological Macromolecules
Xin XuJia-Yi Shi

Abstract

A water-soluble polysaccharide (MCP) was isolated from the fruits of Momordica charantia L., and the hypoglycemic effects of MCP were investigated in both normal healthy and alloxan-induced diabetic mice. MCP was orally administered once a day after 3 days of alloxan-induction at 100, 200 and 300mg/kg body weight for 28 day. Results showed that fasting blood glucose level (BGL) was significantly decreased, whereas the glucose tolerance was marked improvement in alloxan-induced diabetic mice, and loss in body weight was also prevented in diabetic mice compared to the diabetic control group. The dosage of 300mg/kg body weight exhibited the best effects. In addition, MCP did not exhibit any toxic symptoms in the limited toxicity evaluation in mice. The results suggest that MCP possess significantly dose-dependent anti-diabetic activity on alloxan-induced diabetic mice. Hence, MCP can be incorporated as a supplement in health-care food, drugs and/or combined with other hypoglycemic drugs.

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Citations

Dec 3, 2015·International Journal of Biological Macromolecules·Yan ZhangYu Yang
Jul 6, 2016·International Journal of Biological Macromolecules·Fan ZhangJianhua Xie
Nov 24, 2016·Phytotherapy Research : PTR·Zhi-Gang GongYong-Jiang Xu
Nov 29, 2017·International Journal of Molecular Sciences·Shuo JiaJianhua Xie
Sep 7, 2019·International Journal of Environmental Research and Public Health·Meiqi FanSang-Ho Moon
May 17, 2018·Oxidative Medicine and Cellular Longevity·Xueli CaoJianhua Qi
Apr 10, 2019·Polymers·Salima T MinzanovaVasili A Milyukov
Feb 8, 2019·Oxidative Medicine and Cellular Longevity·Zheng Feei MaYifan Zhu
Feb 23, 2019·Journal of Cellular Biochemistry·Naseh PahlavaniHamidreza Rahimi
Jul 26, 2019·BMC Complementary and Alternative Medicine·Muhammad Farooq KhanMohammad A M Wadaan
Feb 1, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Qianghua YuanJing Tan
Nov 15, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gamal A SolimanMaged S Abdel-Kader
Jan 30, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Zhuo LiuHui Dong
Feb 20, 2021·Journal of Agricultural and Food Chemistry·Zhonghua LuoYuqing Zhao
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Qi WangYang Liu
Nov 16, 2021·Frontiers in Pharmacology·Félicien Mushagalusa KasaliAmon Ganafa Agaba

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