PMID: 6978853Jan 1, 1982Paper

Anti-DNA, anti-deoxyribonucleoprotein and rheumatoid factor measured by ELISA in patients with systemic lupus erythematosus, Sjögren's syndrome and rheumatoid arthritis

International Archives of Allergy and Applied Immunology
J KarshA D Steinberg

Abstract

Serum concentrations of anti-DNA and anti-deoxyribonucleoprotein (NP) antibodies were measured in parallel by standardized ELISA methods with a polyvalent anti-immunoglobulin conjugate in patients with systemic lupus erythematosus (SLE), Sjögren's syndrome (SS) and rheumatoid arthritis (RA). High levels of these antibodies predominated in systemic lupus erythematosus. While an appreciable incidence of antibodies also occurred in SS and RA, they were mostly at lower levels. By using heavy chain-specific anti-immunoglobulin conjugates, IgG antibodies to both DNA and NP were found in SLE more frequently and at higher levels than were IgM antibodies. In contrast, IgM antibodies to DNA and NP predominated in SS and RA. The immunoglobulin class of the anti-DNA and anti-NP responses in a given SLE patient were not infrequently different. For example, a patient might show a very high IgG but low IgM anti-DNA value, with the reverse being true for anti-NP. IgG anti-DNA antibodies were significantly associated with depressions of C3. During changes in SLE serology, normalization of DNA binding by Farr radioimmunoassay and/or complement was most frequently associated with normalization of the IgG anti-DNA antibody concentrations. In patie...Continue Reading

Citations

Jul 10, 2003·Autoimmunity Reviews·Rufus W Burlingame, Ricard Cervera
May 3, 2003·Annals of the New York Academy of Sciences·Mark J ShlomchikJacqueline William
Jan 1, 1985·Scandinavian Journal of Rheumatology. Supplement·R SmeenkT Swaak
Oct 19, 2000·Arthritis and Rheumatism·A BrunsF Hiepe

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