Anti-DNA antibodies, autoimmunity and the immunoglobulin repertoire

International Reviews of Immunology
K J Barrett

Abstract

The advent of hybridoma and recombinant DNA technology about a decade ago has allowed a detailed analysis the structure, properties and molecular genetics of antibodies. These techniques, combined with studies of idiotypes and of Abelson-transformed and other cell lines, have resulted in major findings which are of particular importance to both the normal immune system and to autoimmunity. The rearrangement and expression of antibody genes in the normal immune system are discussed first, as a background for an appreciation of the significance of the molecular genetics of autoantibodies. We then turn to autoantibody genes, with an emphasis on anti-DNA antibodies and their role in the autoimmune disease, systemic lupus erythematosus. A model for the genetics of lupus which includes a possible role for Ig genes is considered.

References

May 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·E A KabatH Bilofsky
Jan 1, 1987·Annual Review of Immunology·D A CarsonS Fong
Jan 1, 1987·Annual Review of Immunology·A DavidsonB Diamond
Apr 1, 1988·The Journal of Experimental Medicine·G E Wu, C J Paige
Feb 1, 1985·The Journal of Clinical Investigation·R S Schwartz, B D Stollar
Jan 1, 1987·Immunogenetics·T BlankensteinU Krawinkel
Dec 1, 1986·Immunological Reviews·C PainterC A Bona
Jan 1, 1986·Springer Seminars in Immunopathology·A N TheofilopoulosF J Dixon
Apr 1, 1987·Immunological Investigations·G KroemerR Kofler
Sep 1, 1987·European Journal of Immunology·T Blankenstein, U Krawinkel
Jan 1, 1988·Annual Review of Immunology·C A Bona
Feb 1, 1987·The Journal of Experimental Medicine·P MiglioriniR S Schwartz
Jul 1, 1985·The Journal of Experimental Medicine·R KoflerA N Theofilopoulos
Jan 1, 1986·European Journal of Immunology·M KaartinenO Mäkelä
Feb 1, 1986·Immunological Reviews·F W AltG D Yancopoulos
Apr 3, 1986·Nature·E LötscherH G Zachau
Jan 1, 1986·Immunogenetics·L A D'Hoostelaere, D M Gibson
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J SharonM Ptashne
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·A J Manheimer-LoryC A Bona
Oct 1, 1986·Immunological Reviews·R R Hardy, K Hayakawa
Oct 1, 1986·Immunological Reviews·L A HerzenbergL A Herzenberg
Feb 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·I Sanz, J D Capra
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·A M LawlerP J Gearhart
Apr 3, 1987·Science·R R HardyT Kishimoto
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·A M GiustiM D Scharff

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