PMID: 3764305Jan 1, 1986Paper

Anti-DNA antibodies of IgA class in patients with systemic lupus erythematosus

Rheumatology International
M Gripenberg, T Helve

Abstract

Sera obtained from 53 patients with systemic lupus erythematosus (SLE) were investigated for the presence of immunoglobulin class-specific antibodies against native (ds)DNA and denatured (ss)DNA. The methods employed were the Crithidia luciliae test and an enzyme-linked immunosorbent assay (ELISA), respectively. Anti-dsDNA antibodies of IgG class were seen in 42%, IgM-anti-dsDNA antibodies in 43%, and IgA-anti-dsDNA antibodies in 30% of the patients. There was an association between the presence of both IgG- and IgA anti-dsDNA antibodies and the activity of the disease. Patients with active nephritis also had anti-dsDNA antibodies of IgG and IgA class significantly more often than patients with inactive nephritis or without renal disease. IgG-anti-ssDNA antibodies were seen in 89%, IgM-anti-ssDNA antibodies in 51%, and IgA-anti-ssDNA antibodies in 66% of the patients. Patients with nephritis had low levels of antibodies to ssDNA of IgM class. We suggest that immunoglobulin class-specific anti-DNA antibodies should be determined in the diagnosis and monitoring of SLE.

References

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Citations

Jan 1, 1991·Molecular Aspects of Medicine·S BlountJ Lunec
Dec 30, 1991·Annals of the New York Academy of Sciences·R M KnoblerF Trautinger
Jul 27, 2000·Journal of Clinical Pathology·W Egner
Jun 2, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Abdurahman Saud Al ArfajRashid Ali
Aug 22, 2006·Scandinavian Journal of Immunology·B T Kurien, R H Scofield
Oct 17, 2018·Current Rheumatology Reviews·Ana Isabel Ospina-CaicedoGloria Vásquez Duque
Dec 21, 2013·The Open Rheumatology Journal·Briele KeisermanHenrique Luiz Staub

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