Mar 16, 1976

Anti-dopaminergic and anti-muscarinic effects of dibenzodiazepines: relationship to drug induced Parkinsonism

Naunyn-Schmiedeberg's Archives of Pharmacology
R J Miller, C R Hiley

Abstract

1. The anti-dopaminergic effects of several dibenzodiazepines were examined on the dopamine-stimulated adenylate cyclase in rat striatal homogenates. The "cis" isomer of clozapine, HF-2046, was the most potent in this respect and perlapine, which is devoid of neuroleptic activity, was the weakest. 2. The anti-muscarinic effects of the same compounds were measured by using the muscarinic affinity label 3H-propylbenzilylcholine mustard. HF-2046 was the most potent and loxapine the least potent of the drugs used. 3. The anti-dopaminergic effects of the drugs correlate well with neuroleptic but not with extrapyramidal effects. The anti-dopaminergic/anti-muscarinic ratio, however, correlates well with extrapyramidal rather than neuroleptic effects.

Mentioned in this Paper

Homovanillic Acid
Dibenzothiazepines
Piperazines
Lentiform Nucleus Structure
Loxapine Monohydrochloride
Cholinergic Receptors
Insula of Reil
Antispasmodic Effect
Dibenzazepines
Choline Hydroxide

About this Paper

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