Anti-double Stranded DNA Antibodies: Origin, Pathogenicity, and Targeted Therapies

Frontiers in Immunology
Xiaoyu Wang, Yumin Xia

Abstract

Systemic lupus erythematosus (SLE) is characterized by high-titer serological autoantibodies, including antibodies that bind to double-stranded DNA (dsDNA). The origin, specificity, and pathogenicity of anti-dsDNA antibodies have been studied from a wider perspective. These autoantibodies have been suggested to contribute to multiple end-organ injuries, especially to lupus nephritis, in patients with SLE. Moreover, serum levels of anti-DNA antibodies fluctuate with disease activity in patients with SLE. By directly binding to self-antigens or indirectly forming immune complexes, anti-dsDNA antibodies can accumulate in the glomerular and tubular basement membrane. These autoantibodies can also trigger the complement cascade, penetrate into living cells, modulate gene expression, and even induce profibrotic phenotypes of renal cells. In addition, the expression of suppressor of cytokine signaling 1 is reduced by anti-DNA antibodies simultaneously with upregulation of profibrotic genes. Anti-dsDNA antibodies may even participate in the pathogenesis of SLE by catalyzing hydrolysis of certain DNA molecules or peptides in cells. Recently, anti-dsDNA antibodies have been explored in greater depth as a therapeutic target in the managem...Continue Reading

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Citations

Jun 6, 2020·Expert Opinion on Investigational Drugs·Rossella TalottaMagdalena Janina Laska
Jan 14, 2021·The Kaohsiung Journal of Medical Sciences·Ling-Jung Chiu, Chen-Hsiang Lee
Oct 14, 2020·Trends in Molecular Medicine·Marilyn E AllenGregory L Szeto
Feb 27, 2021·Experimental Neurobiology·So Yeong Cheon, Jong Eun Lee
Apr 4, 2021·International Immunopharmacology·Yuan XiaXiangpei Li
May 11, 2021·Frontiers in Immunology·Manuel Sáez MoyaPablo Engel
Oct 17, 2020·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Fan YangWeihui Zeng
Jul 30, 2021·Arteriosclerosis, Thrombosis, and Vascular Biology·Alejandra María Patiño-TrivesChary López-Pedrera
Sep 21, 2021·Clinical Reviews in Allergy & Immunology·Yaqi WangHuixia Wang
Nov 24, 2021·ACS Biomaterials Science & Engineering·Marilyn E AllenGregory L Szeto

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Methods Mentioned

BETA
transgenic
enzyme-linked immunosorbent assays
ELISAs
ELISA
genetic modification
biopsy

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