Anti-dsDNA and Antichromatin Antibody Isotypes in Serologically Active Clinically Quiescent Systemic Lupus Erythematosus

The Journal of Rheumatology
Amanda J SteimanJoan Wither

Abstract

Serologically active clinically quiescent (SACQ) patients with systemic lupus erythematosus (SLE) are clinically quiescent despite serologic activity. Since studies suggest that antichromatin antibodies are more sensitive than anti-dsDNA antibodies in detecting active SLE, and that immunoglobulin (Ig) G, in particular complement-fixing subclasses, may be more pathogenic than IgM, we investigated the levels of anti-dsDNA and antichromatin isotypes in SACQ patients as compared to non-SACQ patients with SLE. Levels of IgM, IgA, IgG, and IgG1-4 antichromatin and anti-dsDNA were measured by ELISA. SACQ was defined as ≥ 2 years with the SLE Disease Activity Index 2000 (SLEDAI-2K) at 2 or 4 from serologic activity, during which patients could be taking antimalarials, but not corticosteroids or immunosuppressives. Unselected non-SACQ patients with SLE were used as comparators. SACQ patient serum samples were further stratified based on subsequent development of flare, defined as clinical SLEDAI-2K ≥ 1 and/or treatment initiation. Nonparametric statistics were used, and generalized estimating equations were applied to account for multiple samples in the same patient. SACQ patients' complement-fixing antichromatin and anti-dsDNA IgG subc...Continue Reading

References

Mar 7, 1989·Biochemistry·T D YagerK E van Holde
May 8, 1998·The New England Journal of Medicine·B H Hahn
Jan 17, 2003·Lupus·J W C DiekerJ H M Berden
Jun 1, 2005·Rheumatic Diseases Clinics of North America·Murray B Urowitz, Dafna D Gladman
May 15, 2007·Rheumatology·D A IsenbergA Rahman
Jan 15, 2008·Journal of Autoimmunity·Laura AndreoliAngela Tincani
May 21, 2008·Lupus·S MullerP L Meroni
Jun 10, 2008·Seminars in Arthritis and Rheumatism·Aharon KesselElias Toubi
Jul 9, 2008·Autoimmunity Reviews·José A Gómez-PuertaRicard Cervera
Oct 9, 2009·Autoimmunity·Emese KissPeter Szodoray
Mar 17, 2010·Indian Journal of Dermatology, Venereology and Leprology·Vandana D PradhanKanjaksha Ghosh
Apr 9, 2010·International Journal of Rheumatic Diseases·Suleiman SuleimanChe Hussin Che Maraina
Jul 3, 2010·The Journal of Rheumatology·Amanda J SteimanMurray B Urowitz
Aug 16, 2011·Seminars in Nephrology·Johan van der Vlag, Jo H M Berden

❮ Previous
Next ❯

Citations

Nov 20, 2015·Nature Reviews. Rheumatology·David S Pisetsky
Jan 30, 2013·Journal of Immunological Methods·Alessandra DellavanceLuis Eduardo Coelho Andrade
Oct 27, 2017·Arthritis Research & Therapy·Noémie GensousUNKNOWN FHU ACRONIM
Aug 7, 2018·European Journal of Clinical Investigation·Yalan XuJuntao Liu
Jan 17, 2016·The Journal of Rheumatology·Roger C HoMelvyn W Zhang
Mar 21, 2018·Current Rheumatology Reviews·Francesco CarubbiRoberto Giacomelli
Dec 26, 2016·Rheumatology·Cristina ArriensChandra Mohan
Sep 11, 2020·Cell Death & Disease·Hantao LouXiao-Ning Xu
Jul 1, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Matthew A CareGina M Doody
Dec 15, 2020·Lupus·Luis Alonso GonzálezGraciela S Alarcón
Jul 3, 2021·Biomolecules·Haitao YuKeishi Fujio

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.