Anti-emetic Drugs for Prophylaxis of Postoperative Nausea and Vomiting After Craniotomy: An Updated Systematic Review and Network Meta-Analysis

Frontiers in Medicine
Yijing Chen, Jing Chang

Abstract

Background: There is uncertainty about the effect of antiemetic drugs (AED) for the prophylaxis of postoperative nausea and vomiting (PONV) after craniotomy. In this study, we assessed the effectiveness and safety of AED for PONV. Methods and Findings: We searched online databases including the Cochrane Library, PubMed, Wiley, Elsevier Science Direct, Ovid LWW, and Springer for publications from 1985 to June 2018. Adults undergoing craniotomy with the prophylactic use of at least one AED were included. The primary outcomes were the incidence of postoperative nausea (PON) and postoperative vomiting (POV) during the first and second day. A total of 1,433 participants from 17 clinical trials were enrolled in this Network Meta-Analysis (NMA). Compared to placebo, ramosetron was the most effective treatment for PON 24 h after surgery (OR = 0.063, 95% Crl: 0.006-0.45), with a 69.2% probability. On the other hand, for POV, droperidol was the best treatment during the first 2 h with a 71.1% probability (OR = 0.029, 95% Crl: 0.003-0.25); while fosaprepitant was the most effective treatment at 0-24 h (OR = 0.027, 95% Crl: 0.007-0.094; 66.9% probability) and 0-48 h (OR = 0.036, 95% Crl: 0.006-0.18; 56.6% probability). Besides, ramosetron ...Continue Reading

References

Jun 27, 2001·Journal of Neurosurgical Anesthesiology·S KathirvelS Shenoy
Jun 11, 2004·The New England Journal of Medicine·Christian C ApfelUNKNOWN IMPACT Investigators
Feb 22, 2008·Best Practice & Research. Clinical Anaesthesiology·L H J EberhartS Himmelseher
Feb 23, 2010·International Journal of Surgery·David MoherUNKNOWN PRISMA Group
Oct 30, 2010·Journal of Neurosurgery·Björn LatzKristin Engelhard
Dec 21, 2013·Anesthesia and Analgesia·Tong J GanUNKNOWN Society for Ambulatory Anesthesia
Aug 11, 2015·BioMed Research International·Seongheon LeeSeongwook Jeong
Oct 9, 2016·Anaesthesia Critical Care & Pain Medicine·Laurent LonjaretThomas Geeraerts
Nov 9, 2016·The Journal of Neuroscience Nursing : Journal of the American Association of Neuroscience Nurses·Jodi D HellicksonLori M Rhudy

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