Anti-endothelial cell antibodies in rheumatic heart disease.

Clinical and Experimental Immunology
V ScalziG Valesini

Abstract

To evaluate the anti-endothelial cell antibodies (AECA), anti-cardiolipin antibodies (aCL) and serum mannose-binding lectin (MBL) profiles of a large cohort of Yemeni patients with rheumatic heart disease (RHD) and to correlate these findings with clinical features of the disease. Patients (n = 140) were recruited from Al-Thawra Hospital in Sana'a, Yemen. All had RHD diagnosed according to modified Jones' criteria. We also studied 140 sex- and age-matched healthy blood donors from the same area. Echocardiography was performed according to the recommendations of the American Society of Echocardiography. Solid phase enzyme-linked immunosorbent assays (ELISAs) were used to measure AECA and aCL titres and serum MBL levels. Forty per cent of the patients were AECA-positive, but only 7·8% were positive for aCL antibodies. Serum MBL levels were significantly lower in the RHD group (median 4221 ng/ml versus 5166 ng/ml in healthy controls). AECA titres were correlated positively with patient age, duration of RHD and the severity of aortic stenosis, as determined by echocardiographic findings. In several autoimmune rheumatic diseases, such as systemic lupus erythematosus, vasculitis and scleroderma, AECA have been shown to play pathogeni...Continue Reading

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Citations

Nov 26, 2013·Rheumatic Diseases Clinics of North America·Tiphanie VogelKevin Baszis
Jun 28, 2011·Journal of Pediatric Health Care : Official Publication of National Association of Pediatric Nurse Associates & Practitioners·Lori ThompsonJerithea Tidwell
Apr 22, 2015·Autoimmunity Reviews·William John MartinIan P Wicks
Feb 6, 2015·Frontiers in Pediatrics·Marcia Holsbach BeltrameIara José de Messias-Reason
Apr 15, 2018·Pediatric Rheumatology Online Journal·Maher Hassan GomaaMohamed Mohamed Badr
May 15, 2018·Frontiers in Immunology·Lee A Meier, Bryce A Binstadt
Mar 13, 2017·Current Treatment Options in Cardiovascular Medicine·Liesl J ZühlkeJonathan Carapetis
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Nov 25, 2020·Immunology Letters·Sandra Jeremias CatarinoIara Jose Messias-Reason
Oct 13, 2021·Transactions of the Royal Society of Tropical Medicine and Hygiene·Ellen KulikMerlin Willcox

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