Anti-endothelial cell antibodies in systemic sclerosis

Annals of the Rheumatic Diseases
C Mihai, J W C Tervaert

Abstract

Anti-endothelial cell antibodies (AECA) are a heterogeneous class of antibodies whose role in the pathogenesis of autoimmune diseases with vascular involvement has been extensively studied. Systemic sclerosis (SSc) is one of the systemic autoimmune diseases in which endothelial dysfunction is well defined and important in the development of the disease. AECA are present in the serum samples of many patients with SSc. Depending on the detection method and on patient selection, 22-86% of patients test positive for AECA. Among the demonstrated clinical associations, lung and peripheral vascular involvement are the most common. In this paper, the methods of detection, various molecular specificities and the possible pathogenic mechanisms of AECA in SSc are reviewed.

Citations

Oct 29, 2010·International Journal of Rheumatology·Ibrahim BatalSheldon Bastacky
Oct 27, 2011·International Journal of Rheumatology·Toshiyuki Yamamoto, Ichiro Katayama
Sep 19, 2012·International Journal of Rheumatology·Harpreet K Lota, Elisabetta A Renzoni
Sep 3, 2014·La Presse médicale·Mohamed A GashoutaPaul M Hassoun
Jul 18, 2014·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Beate EckesThomas Krieg
Nov 26, 2010·Annual Review of Pathology·Tamiko R KatsumotoM Kari Connolly
Dec 10, 2013·Autoimmune Diseases·Julio C Sartori-ValinottiAnn M Reed
Oct 8, 2013·Rinshō shinkeigaku = Clinical neurology·Yasutaka IwanagaJun-ichi Kira
Dec 8, 2010·Expert Opinion on Biological Therapy·Rie KarasawaTomohiro Kato
Mar 15, 2016·Current Rheumatology Reports·Colin Ligon, Laura K Hummers
Jan 15, 2014·La Revue de médecine interne·Y BenhamouR Joannidès
Sep 10, 2010·International Journal of Rheumatology·Maurizio CutoloVanessa Smith
Jul 15, 2015·Seminars in Immunopathology·Yoshihide Asano, Shinichi Sato
Jun 30, 2012·Autoimmunity Reviews·Sonal MehraMarvin J Fritzler
Dec 31, 2010·Clinical Immunology : the Official Journal of the Clinical Immunology Society·I De VidiT Vincent
Oct 26, 2016·Molecular & Cellular Proteomics : MCP·Chao-Jun HuYong-Zhe Li
May 21, 2015·Pulmonary Circulation·Paul M Hassoun
Aug 19, 2010·The Journal of Rheumatology·Nicoletta Del PapaGiorgio Lambertenghi Deliliers
Apr 23, 2011·Expert Review of Respiratory Medicine·Stephen C Mathai, Paul M Hassoun
Mar 20, 2015·Expert Review of Clinical Immunology·Alireza GhanadanNima Rezaei
Sep 21, 2019·Expert Review of Clinical Immunology·Dušanka Martinović Kaliterna, Marin Petrić
Feb 23, 2020·International Journal of Molecular Sciences·Eun Ha KangYun Jong Lee
May 3, 2019·Expert Review of Clinical Immunology·Maurizio CutoloVanessa Smith
Sep 11, 2018·Frontiers in Physiology·Amaal E AbdulleHarry van Goor
Oct 28, 2020·Journal of Clinical Medicine·Akira UtsunomiyaMinoru Hasegawa
Jun 27, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Eira Cerda ReyesJuan Carlos Garcia-Pagan
Dec 7, 2018·The Journal of Investigative Dermatology·Takashi YamashitaShinichi Sato
Jun 11, 2020·Kidney & Blood Pressure Research·Magdalena ChrabaszczLidia Rudnicka
Oct 1, 2010·Current Opinion in Rheumatology

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