PMID: 7538099Jan 1, 1995Paper

Anti-envelope antibodies in anti-hepatitis C virus (HCV) positive patients with and without liver disease

Infection
M PirisiE Bartoli

Abstract

Our aim was to verify whether the presence of antibodies to HCV envelope protein might mark the occurrence of liver damage, as recently suggested in the literature. Sera from 104 patients (62 male, 42 female) were tested: 84 were positive and 20 were negative to a second generation enzyme immunoassay for anti-HCV antibodies; 51 patients had mild chronic liver disease (44 chronic hepatitis, seven steatosis), 43 had liver cirrhosis (superimposed by hepatocellular carcinoma in 18) and ten were asymptomatic anti-HCV positive subjects with normal liver function tests. Besides, all sera were tested by means of an enzyme immunoassay for the presence of serum antibodies to the synthetic peptide S24A (SIYPGHVSGH RMAWDMMMNW SPTA) derived from amino acids 307-330 of HCV polyprotein. Anti-S24A antibodies were detected in 40/84 sera positive and 1/20 negative at anti-HCV testing (Pearson chi 2 12.29; p = 0.005). Among anti-HCV positive sera, no significant difference existed in anti-S24A status with regard to clinical evidence of liver disease, ALT concentration or HCV RNA positivity. Thus, anti-S24A antibodies are detectable in approximately half of HCV-positive sera, but they do not seem to add significant clinical information to existing...Continue Reading

References

Oct 1, 1991·Journal of Virological Methods·L ImbertiD Primi
Sep 15, 1993·Annals of Internal Medicine·A J Czaja

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Citations

Oct 27, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi BruixUNKNOWN Practice Guidelines Committee, American Association for the Study of Liver Diseases
Jan 24, 2002·Clinical Reviews in Allergy & Immunology·Charles E Reed
Dec 13, 2012·Analytical and Bioanalytical Chemistry·Leticia FernándezIsabel Haro
Mar 20, 1998·Annals of Emergency Medicine·T A Morton, G D Kelen

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