Anti-fatigue Effects of 20(S)-Protopanaxadiol and 20(S)-Protopanaxatriol in Mice

Biological & Pharmaceutical Bulletin
Hyun A OhDong-Hyun Kim

Abstract

Ginseng (Panax ginseng C.A. MEYER, Araliaceae), which contains protopanaxadiol-type and protopanaxatriol-type ginsenosides, has been used for inflammation, fatigue, stress, and tumor in Asian countries. Orally administered ginsenosides are metabolized to their aglycones 20(S)-protopanaxadiol (PPD) and 20(S)-protopanaxatriol (PPT) by gut microbiota. However, their anti-fatigue effects have not been studied thoroughly. Therefore, we investigated the anti-fatigue activities of PPD and PPT in mice, using the weight-loaded swimming (WLS) and the rota-rod tests. Ginseng water extract (GW), ginseng saponin fraction (GWS) and ginseng polysaccharide fraction (GWP) at concentrations of 50 and 100 mg/kg and PPD and PPT at 5 and 10 mg/kg were orally administered to mice once daily for 5 d. GW, GWS, and PPT significantly increased the WLS time, however, GWP and PPD did not cause any significant change. PPT induced the most significant increase in WLS time. PPD (10 mg/kg) and PPT (5 and 10 mg/kg) inhibited the WLS-induced increase in corticosterone, lactate, lactate dehydrogenase (LDH), and creatinine levels as well as the reduction in glucose level. PPT increased the riding time in the rota-rod test, and also inhibited corticosterone, lacta...Continue Reading

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Citations

Mar 25, 2017·Journal of the Science of Food and Agriculture·Jing YeMeitian Xiao
Jan 29, 2019·The American Journal of Hospice & Palliative Care·Mellar P Davis, Bertrand Behm
Mar 31, 2018·Experimental and Therapeutic Medicine·Xue JiangDi Wang
Oct 19, 2016·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Namhun LeeHwa Seung Yoo
Jul 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ze-Yu ShiAlice Sze Tsai Wong
Apr 24, 2020·Frontiers in Neuroscience·Shawn D FlanaganWilliam J Kraemer

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