Anti-fatigue effects of small-molecule oligopeptides isolated from Panax quinquefolium L. in mice

Food & Function
Di LiYong Li

Abstract

American ginseng (Panax quinquefolium L.) was reported to have extensive biological activities and pharmaceutical properties. In most of the studies, the anti-fatigue effects of American ginseng are attributed to ginsenoside, and in only a few studies, they have been attributed to oligopeptides. Therefore, the aim of this study was to observe the anti-fatigue effects of small-molecule oligopeptides isolated from Panax quinquefolium L. (QOPs) in mice. At first, mice chosen for the study were randomly divided into four experimental groups; each group of mice was further divided into five subgroups: vehicle control group, whey protein group (450 mg per kg BW), and three groups of QOPs at different doses (225 mg per kg BW, 450 mg per kg BW, and 900 mg per kg BW). Test substances were given by gavage once a day for 30 days. QOPs can significantly prolong the forced swimming time, decrease the serum urea nitrogen (SUN) and blood lactate (BLA) levels, and increase the lactate dehydrogenase (LDH) activity and hepatic glycogen content. QOPs also markedly enhanced the superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity and attenuated the malondialdehyde (MDA) levels. Notably, QOPs enhanced the activity of succinate de...Continue Reading

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Citations

Feb 6, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jun-Bo WangYong Li
Aug 18, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Shuai ShaoDa-Qing Zhao
Mar 21, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Yanni ZhangYitao Jia
Dec 26, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rui LiuYong Li
May 11, 2021·Journal of Food Science and Technology·Tao FengJunming Mo
Nov 14, 2020·Journal of the Science of Food and Agriculture·Gaoshuang HuDehua Mou
Jun 17, 2021·The Journal of Pharmacology and Experimental Therapeutics·Huijiao LinShu Jing
Oct 26, 2021·Journal of the Science of Food and Agriculture·Lei FangMu-Yi Cai
Nov 29, 2021·Journal of the Science of Food and Agriculture·Zhiyuan FengMuyi Cai

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Methods Mentioned

BETA
MDA
PCR
reverse transcription-PCR

Software Mentioned

SPSS

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