PMID: 9187028Apr 1, 1997Paper

Anti-fecundity immunity to Schistosoma japonicum induced in Chinese water buffaloes (Bos buffelus) after vaccination with recombinant 26 kDa glutathione-S-transferase (reSjc26GST)

Veterinary Parasitology
L ShuxianD P McManus

Abstract

We have shown previously that immunisation of mice and pigs with recombinant 26 kDa GST (reSjc26GST) induces a pronounced anti-fecundity effect after experimental infection with Chinese Schistosoma japonicum. We report here that anti-fecundity immunity can also be induced against reSjc26GST in Chinese water buffaloes (Bos buffelus), important reservoir hosts for S. japonicum in China. Anti-Sjc26GST antibodies were produced in immunised buffaloes and, following challenge with S. japonicum cercariae, a 22.3% reduction in worm numbers was evident in vaccinated when compared with control animals. The anti-fecundity effect was characterised by a significant decrease in faecal egg output and eggs deposited in host tissues with those in the liver and intestine being reduced by about 50%. In addition to the anti-fecundity effect, reSjc26GST reduced by nearly 40% the egg-hatching capacity of S. japonicum eggs into viable miracidia. In terms of vaccination strategy, these effects would combine to diminish pathology in animals immunised with reSjc26GST and reduce transmission of schistosomiasis japonica.

References

Aug 1, 1992·Molecular and Biochemical Parasitology·F TrotteinA Capron
Mar 12, 1987·Nature·J M BalloulA Capron
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D B SmithG F Mitchell
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Citations

Apr 15, 2004·Parasitology International·Donald P McManus, Paul B Bartley
Mar 17, 2000·International Journal for Parasitology·D P McManus
Oct 26, 2002·Vaccine·Fuhui ShiMartin G Taylor
Oct 16, 2002·Trends in Microbiology·Pierre DruilheGraham A W Rook
Jun 26, 2001·Trends in Parasitology·Y X HeK Ramaswamy
Sep 20, 2005·Acta Tropica·Zhong-Dao WuXin-Bing Yu
Nov 2, 2014·Parasitology·Hong You, Donald P McManus
Mar 31, 2018·Advanced Healthcare Materials·Pengyang LiBo Wang
Dec 29, 2000·The Journal of Parasitology·I M CesariD Bout
Oct 3, 2018·Tropical Medicine and Infectious Disease·Hong YouDonald P McManus

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