PMID: 18949334Oct 25, 2008Paper

Anti-flagellin antibody responses elicited in mice orally immunized with attenuated Salmonella enterica serovar Typhimurium vaccine strains

Memórias do Instituto Oswaldo Cruz
L M MassisL C S Ferreira

Abstract

In the present study we investigated the flagellin-specific serum (IgG) and fecal (IgA) antibody responses elicited in BALB/c mice immunized with isogenic mutant derivatives of the attenuated Salmonella enterica serovar Typhimurium (S. Typhimurium) SL3261 strain expressing phase 1 (FliCi), phase 2 (FljB), or no endogenous flagellin. The data reported here indicate that mice orally immunized with recombinant S. Typhimurium strains do not mount significant systemic or secreted antibody responses to FliCi, FljB or heterologous B-cell epitopes genetically fused to FliCi. These findings are particularly relevant for those interested in the use of flagellins as molecular carriers of heterologous antigens vectored by attenuated S. Typhimurium strains.

References

Jan 1, 1991·Advances in Experimental Medicine and Biology·R N BreyM I Sabara
Jan 1, 1971·Molecular & General Genetics : MGG·H Schmieger
Jan 1, 1994·International Reviews of Immunology·B A Stocker, S M Newton
Jun 1, 2000·Proceedings of the National Academy of Sciences of the United States of America·K A Datsenko, B L Wanner
Jan 3, 2001·The Journal of Clinical Investigation·Andrew T GewirtzJ L Madara
Nov 5, 2002·FEMS Microbiology Reviews·Helen S GarmoryRichard W Titball
Nov 14, 2002·Annual Review of Genetics·Donald L CourtLynn C Thomason
Dec 13, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Natasha K CrellinMegan K Levings
Aug 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Catherine J SandersAndrew T Gewirtz

Citations

Aug 21, 2010·Molecular Biotechnology·Louis-Philippe Bergeron-SandovalFathey Sarhan
Feb 18, 2011·FEMS Microbiology Letters·Borja SánchezMaría C Urdaci
Aug 19, 2020·Research Quarterly for Exercise and Sport·Tan ZhangAng Chen

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