Anti-Fumarase Antibody as a Predictor of Functional Efficacy of Anti-VEGF Therapy for Diabetic Macular Edema

Investigative Ophthalmology & Visual Science
Tatsuya YoshitakeAkitaka Tsujikawa

Abstract

To evaluate whether baseline titers of anti-fumarase antibody are associated with visual prognosis after anti-VEGF treatment for diabetic macular edema (DME). In this retrospective study, we investigated 52 eyes of 52 DME patients who received intravitreal injections of anti-VEGF drugs (ranibizumab or aflibercept) after blood sampling at baseline. Optical coherence tomography (OCT) images were obtained at every monthly visit. The serum titer of anti-fumarase antibody at baseline was measured using ELISA. We evaluated the relationship between the titer of anti-fumarase antibody at baseline and visual acuity (VA) improvement at 12 months. The serum titer of anti-fumarase IgG was related to the logMAR visual acuity (VA; R = 0.329, P = 0.017) and the disrupted ellipsoid zone (EZ; R = 0.364, P = 0.008) at baseline. The titer of this autoantibody was not associated with logMAR VA (R = -0.007, P = 0.980) but was associated with VA improvement (R = 0.465, P < 0.001) at 12 months upon anti-VEGF treatment. The transverse length of the disrupted EZ line was shortened at 12 months (P < 0.001), and restoration of the EZ line was correlated to the autoantibody titer (R = 0.396, P = 0.004) compared with the decrease in central subfield (CSF) ...Continue Reading

References

Sep 1, 2001·American Journal of Ophthalmology·J B Jonas, A Söfker
Jan 1, 2003·Survey of Ophthalmology·Thomas W GardnerSteven W Levison
Dec 12, 2003·Nature Reviews. Immunology·J Wayne Streilein
Apr 28, 2004·The International Journal of Biochemistry & Cell Biology·Nicole S Harhaj, David A Antonetti
Aug 26, 2004·Kidney International·Michael CusickUNKNOWN Early Treatment Diabetic Retinopathy Study Research Group
Dec 26, 2006·American Journal of Ophthalmology·Tomoaki MurakamiNagahisa Yoshimura
Mar 28, 2008·Nature·Mark E KleinmanJayakrishna Ambati
Feb 4, 2010·Ophthalmology·Lloyd Paul AielloUNKNOWN Diabetic Retinopathy Clinical Research Network
Feb 13, 2010·Japanese Journal of Ophthalmology·Yumiko OjimaNagahisa Yoshimura
Mar 20, 2010·Ophthalmology·UNKNOWN Diabetic Retinopathy Clinical Research Network Writing CommitteeMargaret E Stockman
Apr 30, 2010·Ophthalmology·UNKNOWN Diabetic Retinopathy Clinical Research NetworkJennifer K Sun
Jul 9, 2010·American Journal of Ophthalmology·Akio OishiYasuo Kurimoto
Sep 22, 2010·Ophthalmology·Quan Dong NguyenUNKNOWN READ-2 Study Group
Apr 22, 2011·Ophthalmology·William E Smiddy
Feb 4, 2012·Diabetes Care·Joanne W Y YauUNKNOWN Meta-Analysis for Eye Disease (META-EYE) Study Group
Feb 11, 2012·Investigative Ophthalmology & Visual Science·Tomoaki MurakamiNagahisa Yoshimura
Feb 15, 2012·Ophthalmology·Quan Dong NguyenUNKNOWN RISE and RIDE Research Group
Mar 30, 2012·The New England Journal of Medicine·David A AntonettiThomas W Gardner
Apr 28, 2012·Ophthalmology·Diana V DoUNKNOWN da Vinci Study Group
May 12, 2012·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Akio OishiYasuo Kurimoto
Sep 12, 2012·Archives of Ophthalmology·Michael S IpJason S Ehrlich
Sep 12, 2012·Archives of Ophthalmology·Susan B BresslerUNKNOWN Diabetic Retinopathy Clinical Research Network
Feb 26, 2013·Nature Reviews. Immunology·Ravid ShechterMichal Schwartz
May 25, 2013·Nature Reviews. Immunology·Jayakrishna AmbatiBradley D Gelfand
Mar 13, 2014·Investigative Ophthalmology & Visual Science·Tomoaki MurakamiNagahisa Yoshimura
Jul 12, 2014·Ophthalmology·Jean-François KorobelnikDavid M Brown
Oct 11, 2015·The British Journal of Ophthalmology·Christian PrünteUNKNOWN RETAIN Study Group

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.