Anti-fungal activity, mechanism studies on α-Phellandrene and Nonanal against Penicillium cyclopium

Botanical Studies
Ji-Hong ZhangTao-Tao Wang

Abstract

Essential oils from plants have been reported to have wide spread antimicrobial activity against various bacterial and fungal pathogens, and these include α-Phellandrene, Nonanal and other volatile substances. However, biological activities of α-Phellandrene and Nonanal have been reported only in a few publications. Further investigations are necessary to determine the antimicrobial activity of these compounds, especially for individual application, to establish the possible mechanism of action of the most active compound. The results are shown that α-Phellandrene and Nonanal have a dose-dependent inhibition on the mycelial growth of Penicillium cyclopium. The minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) are 1.7 and 1.8 mL/L for α-Phellandrene, 0.3 and 0.4 mL/L for Nonanal, respectively. The volatile compounds altered the morphology of P. cyclopium hyphae by causing loss of cytoplasmic material and distortion of the mycelia. The membrane permeability of P. cyclopium increased with increasing concentrations of the two volatile compounds, as evidenced by cell constituent release, extracellular conductivity and induced efflux of K(+). Moreover, the two volatile compounds induced a decrease in p...Continue Reading

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Citations

Feb 16, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Oberdan Oliveira FerreiraEloisa Helena de Aguiar Andrade
Jan 31, 2020·Phytotherapy Research : PTR·Jayanta Kumar PatraHan-Seung Shin
Jan 2, 2021·Frontiers in Microbiology·Débora Moraes de OliveiraAna Carolina Gomes Jardim
Feb 25, 2021·Experimental & Applied Acarology·Darcy Adriann Rebonato LunsCarlos Logullo
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Reza ManzuoerhAli Sonboli
Oct 19, 2021·Frontiers in Plant Science·Nasie ConstantinoRalph A Dean

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Methods Mentioned

BETA
Scanning electron microscopy

Software Mentioned

SPSS

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