Anti-ganglionic AChR antibodies in Japanese patients with motility disorders

Journal of Gastroenterology
Akihiro MukainoShunya Nakane

Abstract

The existence of several autoantibodies suggests an autoimmune basis for gastrointestinal (GI) dysmotility. Whether GI motility disorders are features of autoimmune autonomic ganglionopathy (AAG) or are related to circulating anti-ganglionic acetylcholine receptor (gAChR) antibodies (Abs) is not known. The aim of this study was to determine the associations between autonomic dysfunction, anti-gAChR Abs, and clinical features in patients with GI motility disorders including achalasia and chronic intestinal pseudo-obstruction (CIPO). First study: retrospective cohort study and laboratory investigation. Samples from 123 patients with seropositive AAG were obtained between 2012 and 2017. Second study: prospective study. Samples from 28 patients with achalasia and 14 patients with CIPO were obtained between 2014 and 2016, and 2013 and 2017, respectively. In the first study, we analyzed clinical profiles of seropositive AAG patients. In the second study, we compared clinical profiles, autonomic symptoms, and results of antibody screening between seropositive, seronegative achalasia, and CIPO groups. In the first study, we identified 10 patients (8.1%) who presented with achalasia, or gastroparesis, or paralytic ileus. In the second s...Continue Reading

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Citations

Nov 26, 2019·Rinshō shinkeigaku = Clinical neurology·Shunya Nakane
May 17, 2019·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Elisabeth P Golden, Steven Vernino
Feb 23, 2020·Arthritis Research & Therapy·Shunya NakaneAtsushi Kawakami
Oct 26, 2018·Expert Review of Neurotherapeutics·Shunya NakaneYukio Ando
Jan 31, 2020·Continuum : Lifelong Learning in Neurology·Steven Vernino
Sep 15, 2020·Muscle & Nerve·Divpreet KaurPaola Sandroni
Feb 24, 2021·Annals of Clinical and Translational Neurology·Makoto YamakawaShunya Nakane
Feb 15, 2021·Journal of Digestive Diseases·Xing Yue WuPing Hong Zhou
May 26, 2021·Journal of Gastroenterology and Hepatology·Shinwa TanakaHaruhiro Inoue

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