Anti-ganglioside antibodies were not detected in human subjects infected with or vaccinated against 2009 pandemic influenza A (H1N1) virus

Vaccine
Ting LeiDong-Yan Jin

Abstract

Recipients of influenza A (H1N1) vaccine in 1976 had an increased risk for the neurologic disorder Guillain-Barré syndrome (GBS). Anti-ganglioside antibodies, which might be associated with the development of GBS, were previously reported to be induced in mice immunized with an H1N1 vaccine of 1976 or another influenza vaccine. In this study we analyzed anti-ganglioside antibodies in human subjects infected with or vaccinated against 2009 pandemic H1N1, including eight patients diagnosed to have post-vaccination GBS. Antibodies against GM1 or another ganglioside were not detected in any subject or in vaccinated mice. Our results did not support the induction of anti-ganglioside antibodies by influenza viruses or vaccines.

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Citations

Apr 6, 2013·Expert Review of Clinical Immunology·Olga Vera-LastraYehuda Shoenfeld
May 23, 2015·Vaccine·L H Martín AriasA Carvajal
Nov 28, 2013·Neuroimmunomodulation·Mazyar HashemilarFaeghe Ebrahimi
Sep 28, 2013·Expert Review of Clinical Immunology·Daniel A SalmonNeal A Halsey
Jul 27, 2017·Influenza and Other Respiratory Viruses·Subhashini A SellersWilliam A Fischer
Sep 4, 2012·Current Opinion in Neurology·Govind Chavada, Hugh J Willison
Oct 13, 2017·The EPMA Journal·Maria VadalàBeniamino Palmieri
Nov 7, 2020·Brain and Behavior·Daiva RadzišauskienėRūta Mameniškienė

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