Anti-GBM Disease in Pregnancy: Acute Renal Failure Resolved After Plasma Exchange, Hemodialysis, and Steroids

Journal of Investigative Medicine High Impact Case Reports
Mohammed Muqeet AdnanBenjamin Jr Cowley

Abstract

Antiglomerular basement membrane (GBM) disease presenting during pregnancy is uncommon. We present a case of a pregnant female who presented with acute renal failure requiring dialysis due to anti-GBM disease. She responded well to plasma exchange, high-dose steroids, and hemodialysis. Cyclophosphamide was discussed but not given at the patient's request due to concerns for the well-being of the fetus. Unfortunately, she suffered a spontaneous abortion in her eighth week of pregnancy. Subsequently, she had progressive improvement in her renal function and became hemodialysis independent at 2 weeks after diagnosis. Her renal function returned to baseline 3 months after diagnosis. We present this case in detail and review the literature regarding anti-GBM disease in pregnancy.

References

Jan 1, 1986·Acta Medica Scandinavica·D E NilssenE K Brodwall
Feb 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·H DeubnerC E Alpers
Jan 25, 2014·Journal of Autoimmunity·Thomas Hellmark, Mårten Segelmark

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Citations

Apr 6, 2021·Case Reports in Nephrology·F A K LodhiR Blonsky

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Methods Mentioned

BETA
biopsy

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