Anti-GBM glomerulonephritis in mice lacking nitric oxide synthase type 2

Kidney International
V CattellF Y Liew

Abstract

Nitric oxide is synthesized in experimental immune complex glomerulonephritis due to local induction of type 2 nitric oxide synthase (NOS2). To determine the role of NOS2, the course of accelerated anti-glomerular basement membrane glomerulonephritis (anti-GBM) was examined in mice homozygous for disruption of the NOS2 gene compared with heterozygous littermates. Disease in the wild type strain (129Sv) was characterized by heavy albuminuria, glomerular neutrophil and macrophage infiltration and glomerular thrombosis. NOS2, interleukin 1B (IL-1 beta) and tumor necrosis factor alpha (TNF alpha) mRNA were induced by 24 hours. The NOS2-deficient mutant mice and the heterozygous mice displayed early (24 hr) and full autologous phase (day 6) injury indistinguishable from the wild-type mice. The equivalent degree of albuminuria and glomerular inflammation indicates that NOS2 does not play an essential role in this form of glomerulonephritis in the mouse.

References

Feb 1, 1978·The Journal of Experimental Medicine·G F SchreinerE R Unanue
Nov 1, 1992·The Journal of Clinical Investigation·P J Shultz, L Raij
Dec 1, 1990·Kidney International·V CattellS Moncada
Jan 1, 1985·Virchows Archiv. A, Pathological Anatomy and Histopathology·K J AssmannR A Koene
Dec 1, 1974·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·I W McLean, P K Nakane
Sep 1, 1982·Kidney International·J NeugartenD S Baldwin
Apr 1, 1994·Kidney International·A JansenV Cattell
Aug 1, 1994·The American Journal of Physiology·K UjiieR A Star
May 1, 1995·Journal of the American Society of Nephrology : JASN·J NeugartenD Schlondorff
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·I NaritaN A Noble
Sep 1, 1993·The American Journal of Physiology·J GabouryP Kubes
Jun 7, 1996·Biochimica Et Biophysica Acta·H SakuraiT Sugita
Jun 1, 1996·Kidney International·C Baylis, C Qiu
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·J D MacMickingC F Nathan
Oct 18, 1958·Nature·W F COOK, G W PICKERING

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Citations

Feb 24, 2000·The Journal of Pathology·L Harper, C O Savage
Feb 19, 2002·Kidney International·Victoria Cattell
Jan 17, 2008·Proceedings of the National Academy of Sciences of the United States of America·Shreeram AkileshAndrey S Shaw
Nov 18, 1998·Current Opinion in Nephrology and Hypertension·S Klahr
Aug 24, 1999·Current Opinion in Nephrology and Hypertension·P G TippingS R Holdsworth
Jul 14, 2010·Seminars in Nephrology·Jeremy S Duffield
Jul 15, 2004·Seminars in Nephrology·Howard Trachtman
Nov 29, 2001·Rheumatic Diseases Clinics of North America·L Harper, C O Savage
Oct 19, 2005·Nephron. Physiology·Joseph SatrianoKaren A Munger
Jun 17, 2016·American Journal of Physiology. Renal Physiology·Hajeong LeeSeung Hee Yang
Dec 24, 2002·American Journal of Physiology. Renal Physiology·Mirjana Poljakovic, Katarina Persson
Oct 7, 2004·The Journal of Nutrition·Gautam Cherla, Edgar A Jaimes
Feb 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·J S DuffieldJ S Savill
Mar 16, 2021·American Journal of Physiology. Renal Physiology·Jung Nam AnSeung Hee Yang
Aug 31, 2000·Journal of the American Society of Nephrology : JASN·John Michael BonviniRudolf P Wüthrich

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