PMID: 8603792Jan 1, 1996Paper

Anti-genotoxic effects in mice after the interaction between coffee and dietary constituents

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Suresh K Abraham

Abstract

The interaction between coffee (100 mg freeze-dried home brew/kg body weight) and dietary constituents was assessed for anti-genotoxic effects against cyclophosphamide, N-methyl-N-nitro-N- nitrosoguanidine (MNNG), N-nitroso-N-ethylurea, mitomycin C and urethane (URE) in the mouse bone marrow micronucleus test. Combinations of dietary constituents consisting of (1) chlorogenic acid, caffeic acid, ellagic acid and ferulic acid, (2) beta-carotene, curcumin and alpha-tocopherol, (3) chlorogenic acid, curcumin, alpha-tocopherol, anethole and eugenol, and (4) beta-carotene, curcumin, ellagic acid and chlorogenic acid were used in this study. Before the genotoxin was injected i.p., identical groups of mice were orally administered either vehicle control, coffee, dietary constituents, or coffee plus dietary constituents. Co-administration of coffee with the dietary constituents enhanced the anti-genotoxic effect compared with that of either coffee or the dietary constituents alone. Two-factor analysis of variance of the data suggests that there is a significant synergistic interaction between coffee and the dietary constituents for anti-genotoxic effects against MNNG (combination 1 and 2) and URE (combination 4).

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Citations

Jun 18, 2002·European Journal of Pharmacology·Tomas de PaulisPeter R Martin
Aug 4, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A N Wijewickreme, D D Kitts
Sep 25, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P NewberneR A Ford
Sep 3, 1998·Mutation Research·E Gonzáez de MejíaG Loarca-Piña
Apr 23, 2013·Environmental Toxicology and Pharmacology·Prashantha NaikRajeev Bhat
Apr 14, 2015·Environmental Toxicology and Pharmacology·L N CariddiA M Dalcero
May 6, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Wylly Ramsés García-Niño, Cecilia Zazueta
Sep 28, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P F M R PáduaH H R de Andrade
Aug 10, 2017·Journal of Food Protection·Zhen-Shu LiuTai-Chen Kuo
Jun 25, 2019·Frontiers in Microbiology·Ioanna MantzouraniEugenia Bezirtzoglou

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