Anti-genotoxicity of coffee against N-methyl-N-nitro-N-nitrosoguanidine in mouse lymphoma cells

Mutation Research
S K Abraham, H Stopper

Abstract

The main aim of this work was to test the hypothesis that instant coffee, a commonly consumed polyphenolic beverage with antioxidant activity, can protect mammalian cells against genotoxic effects in vitro. For this purpose, the L5178Y mouse lymphoma cell line was selected to assess modulatory effects of coffee on the genotoxicity of N-methyl-N-nitro-N-nitrosoguanidine (MNNG). We initiated the work with a set of preliminary experiments in which the cytokinesis-block micronucleus test was performed. Results obtained from these experiments demonstrated a dose-related decrease in genotoxicity following co-treatment of mouse lymphoma cells with three doses of caffeinated instant coffee. Both pre-treatment and co-treatment showed significant antigenotoxic effects against MNNG. Caffeinated and decaffeinated instant coffee samples inhibited genotoxicity. There was no significant change in the antigenotoxic effect of caffeinated instant coffee after filtration using a 0.2 microm filter. Similar in vitro experiments demonstrated antigenotoxic effects against MNNG when boiled coffee was used instead of instant coffee. On the basis of the findings from the above preliminary experiments, further work was carried out to evaluate the possibl...Continue Reading

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Citations

Apr 4, 2008·Cancer Causes & Control : CCC·Brian C-H ChiuDennis D Weisenburger
Aug 21, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jimena BravoConcepcion Cid
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Oct 24, 2013·The Science of the Total Environment·Armando ZarrelliMarina Isidori
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Feb 28, 2018·Drug and Chemical Toxicology·Isha Nagpal, Suresh K Abraham
Nov 6, 2018·International Journal of Molecular Sciences·Deborah BauerAnderson Teodoro
Oct 7, 2016·Drug and Chemical Toxicology·Manoswini ChakrabartiAnita Mukherjee

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