Anti-glioma properties of DVL, a lectin purified from Dioclea violacea

International Journal of Biological Macromolecules
Ana Paula Machado NascimentoRodrigo Bainy Leal

Abstract

Plant lectins have been studied owing to their structural properties and biological effects that include agglutinating activity, antidepressant-like effect and antitumor property. The results from this work showed the effects of the lectin extracted from the Dioclea violacea plant (DVL) on the C6 rat glioma cell line. DVL treatment was able to induce caspase-3 activation, apoptotic cell death and cellular membrane damage. Furthermore, DVL decreased mitochondrial membrane potential and increased the number of acidic vesicles and cleavage of LC3, indicating activation of autophagic processes. DVL also significantly inhibited cell migration. Compared to ConA, a well-studied lectin extracted from Canavalia ensiformes seeds, some effects of DVL were more potent, including decreasing C6 glioma cell viability and migration ability. Taken together, the results suggest that DVL can induce glioma cell death, autophagy and inhibition of cell migration, displaying potential anti-glioma activity.

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Citations

Oct 18, 2019·Current Neuropharmacology·João Ronielly Campêlo AraújoAna Cristina de Oliveira Monteiro-Moreira
Dec 24, 2018·International Journal of Molecular Sciences·Benildo S CavadaKyria S Nascimento
Jun 9, 2020·BioMed Research International·Milena Mazalovska, J Calvin Kouokam
Aug 11, 2019·International Journal of Biological Macromolecules·Priscila Marcelino Dos Santos SilvaLuana Cassandra Breitenbach Barroso Coelho
Sep 23, 2019·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Abtar MishraRohan Dhiman
Nov 15, 2019·International Journal of Biological Macromolecules·Valdenice F SantosClaudener S Teixeira
May 21, 2019·International Journal of Biological Macromolecules·Benildo Sousa CavadaKyria Santiago Nascimento
May 6, 2019·International Journal of Biological Macromolecules·Ana Paula M NascimentoRodrigo B Leal
Apr 11, 2020·International Journal of Biological Macromolecules·Kyria S NascimentoBenildo S Cavada

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