Anti-glomerular basement membrane glomerulonephritis: a morphologic study of 80 cases

American Journal of Clinical Pathology
Edgar G Fischer, Donna J Lager

Abstract

Anti-glomerular basement membrane (anti-GBM) glomerulonephritis is a rare disease caused by IgG autoantibodies against the glomerular basement membrane. We describe clinical and pathologic findings in a series of renal biopsy specimens from 80 patients. The patients ranged in age from 16 to 87 years. The age distribution was bimodal, with one peak at a young age predominated by males and a second peak in the sixth to eighth decades with females predominating. Most patients (70 [88%]) had severe necrotizing glomerulonephritis with crescents in more that 50% of glomeruli. The fraction of crescentic glomeruli in biopsy specimens correlated well with serum creatinine levels but not with serologic titers for anti-GBM antibodies. Interstitial fibrosis was uncommon and, when present, minimal to mild. Linear IgG deposition defines this entity, but immunofluorescent costaining for other immunoglobulins and complement is found frequently. To our knowledge, this is the largest series of renal biopsy specimens with anti-GBM glomerulonephritis studied to date.

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Citations

Jul 6, 2014·Case Reports in Nephrology·Vinay MinochaAndreea Poenariu
Oct 15, 2014·Clinical Reviews in Allergy & Immunology·Maria Sole ChimentiRoberto Perricone
Jul 20, 2011·Nature Reviews. Nephrology·Zhao Cui, Ming-Hui Zhao
Oct 4, 2008·The New England Journal of Medicine·Zachary D GoldbergerBessie A Young
Aug 28, 2012·Clinical Rheumatology·Allan BayatTroels Herlin
Jun 2, 2020·Frontiers in Pediatrics·Antonio MastrangeloGiovanni Montini
Apr 6, 2020·Current Allergy and Asthma Reports·Mary Buckley, Heather Van Mater
Nov 19, 2010·International Urology and Nephrology·Chidi C OkaforE M Abdel-Rahman
Jun 3, 2017·Case Reports in Nephrology·Vimal Master Sankar RajSarah Elhadi
Jul 30, 2010·Trends in Molecular Medicine·Tanya N MayadasSanjeev Sethi
Dec 21, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Zhao CuiMing-hui Zhao

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