Anti-Glomerular Basement Membrane Disease

Clinical Journal of the American Society of Nephrology : CJASN
Stephen P McAdoo, Charles D Pusey

Abstract

Anti-glomerular basement membrane (anti-GBM) disease is a rare small vessel vasculitis that affects the capillary beds of the kidneys and lungs. It is an archetypic autoimmune disease, caused by the development of directly pathogenic autoantibodies targeting a well characterized autoantigen expressed in the basement membranes of these organs, although the inciting events that induce the autoimmune response are not fully understood. The recent confirmation of spatial and temporal clustering of cases suggests that environmental factors, including infection, may trigger disease in genetically susceptible individuals. The majority of patients develop widespread glomerular crescent formation, presenting with features of rapidly progressive GN, and 40%-60% will have concurrent alveolar hemorrhage. Treatment aims to rapidly remove pathogenic autoantibody, typically with the use of plasma exchange, along with steroids and cytotoxic therapy to prevent ongoing autoantibody production and tissue inflammation. Retrospective cohort studies suggest that when this combination of treatment is started early, the majority of patients will have good renal outcome, although presentation with oligoanuria, a high proportion of glomerular crescents, ...Continue Reading

References

Jan 1, 1990·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M SegelmarkJ Wieslander
Feb 1, 1986·British Medical Journal·C O SavageC M Lockwood
May 1, 1988·The Journal of Pathology·S J CashmanD J Evans
Jan 1, 1972·Annals of Internal Medicine·C B Wilson, R C Smith
Feb 1, 1973·Kidney International·C B Wilson, F J Dixon
Dec 1, 1967·The Journal of Experimental Medicine·R A LernerF J Dixon
Jan 1, 1982·American Journal of Nephrology·I J SimpsonC B Wilson
May 1, 1995·Clinical and Experimental Immunology·C J DerryC D Pusey
Jan 23, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A XenocostasM Levy
Apr 8, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·J D Briggs, E Jones
Jun 1, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·C García-CantónD Checa
Aug 3, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·K LaczikaW Druml
Sep 25, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·J C Jennette, D B Thomas
Mar 29, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Michael C ByrneDavid W Ploth
Jun 5, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Alan D SalamaCharles D Pusey
Mar 13, 2003·Kidney International·J Charles Jennette
Sep 13, 2003·Kidney International·Charles D Pusey
May 1, 1958·Australasian Annals of Medicine·M C STANTON, J D TANGE
Jan 14, 2004·Kidney International·Gemma BrowneA Neil Turner
Jun 17, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ulf PerssonMårten Segelmark
Oct 2, 2004·Kidney International·Jeremy B LevyCharles D Pusey
Jun 1, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Zhao Cui, Ming-Hui Zhao
Aug 23, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Abraham RutgersJan Willem Cohen Tervaert
Aug 17, 2006·Pediatric Transplantation·Clifford E Kashtan
Aug 31, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·B Y ChoyK N Lai
May 17, 2007·Medicine·Romain LazorUNKNOWN Swiss Group for Interstitial and Orphan Lung Diseases (SIOLD)
Sep 14, 2007·Kidney International·Z CuiH-y Wang
Jan 25, 2008·Journal of the American Society of Nephrology : JASN·Juan ZouRichard G Phelps
Apr 17, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Wataru KitagawaSatoshi Sugiyama
Aug 16, 2008·The New England Journal of Medicine·Menna R ClatworthyDavid R Jayne
Dec 18, 2008·Clinical Transplantation·Matthias SauterThomas Sitter

❮ Previous
Next ❯

Citations

Feb 27, 2018·Blood Purification·Zdenka Hruskova, Vladimir Tesar
Aug 9, 2018·The New England Journal of Medicine·Ronald J FalkIvy A Rosales
Sep 4, 2018·Expert Review of Clinical Immunology·Eric J CampbellRosalind Ramsey-Goldman
Jan 17, 2019·American Journal of Physiology. Renal Physiology·Stefanie KlingeHans-Willi Mittrücker
May 23, 2019·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Roman David Bülow, Peter Boor
Jul 20, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Xiaojuan GuoGuo Chen Zhao
Dec 17, 2019·The Journal of International Medical Research·Chenni GaoXiaonong Chen
Feb 12, 2020·Journal of Clinical Medicine·Wisit KaewputWisit Cheungpasitporn
Mar 4, 2020·The Journal of Pathology·Benjamin J Stewart, Menna R Clatworthy
Feb 1, 2019·Terapevticheskiĭ arkhiv·M L BulanovaL V Lysenko Kozlovskaya
Mar 30, 2019·British Journal of Haematology·Elisabetta ZanattaFranco Cozzi
Apr 23, 2020·Indian Journal of Pathology & Microbiology·Srinivasrao VavilapalliSree Bhushan Raju
Aug 11, 2018·Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia·Rafia ChaudhryArif Asif
Oct 16, 2019·Experimental and Therapeutic Medicine·Ting WuPing Xiao
Aug 1, 2018·Frontiers in Immunology·Laura RennertFlorian Grahammer
Jul 19, 2020·Journal of the American Society of Nephrology : JASN·Satoru KudoseVivette D D'Agati
Sep 27, 2020·International Journal of Molecular Sciences·Foteini Moschovaki-FilippidouMaciej Lech
May 3, 2019·Oxford Medical Case Reports·Babikir KheiriBasim Towfiq
Nov 22, 2019·World Journal of Transplantation·Maurizio Salvadori, Aris Tsalouchos
Aug 26, 2020·Nature Reviews. Nephrology·Richard W NaylorRachel Lennon
Jun 15, 2019·Oxford Medical Case Reports·Benjamin NortonRichard Hull
Sep 30, 2020·Advances in Anatomic Pathology·Mohammed AkhtarMuhammad Asim
Dec 30, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ulrich SpecksFernando C Fervenza
Jan 10, 2021·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Syeda B AhmadGerald B Appel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.