PMID: 8601708Mar 28, 1996Paper

Anti-gp130 transducer monoclonal antibodies specifically inhibiting ciliary neurotrophic factor, interleukin-6, interleukin-11, leukemia inhibitory factor or oncostatin M

Journal of Immunological Methods
Z J GuB Klein

Abstract

Five cytokines activate the gp130 IL-6 transducer: ciliary neurotrophic factor, interleukin-6, interleukin-11, leukemia inhibitory factor and oncostatin M. Human plasmacytoma cell lines, completely dependent on the addition of one of these five cytokines for their growth, were used to obtain anti-gp130 monoclonal antibodies specifically inhibiting one of these five cytokines without affecting the biological activity of the others. These antibodies should improve our understanding of the interaction of gp130 transducer using cytokines with gp130 transducer and facilitate the design of new cytokine inhibitors.

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Citations

Jan 11, 2002·European Journal of Biochemistry·Xiao-Ming WangJean Content
Oct 29, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Jalal A JazayeriGraeme J Carroll
Nov 10, 2015·Biochimie·Rebecca NitzChristoph Garbers
Jul 13, 2005·Cytokine·Stefania MilitiOttaviano Serlupi-Crescenzi
Jun 24, 2016·Cell Biochemistry and Biophysics·Eugene A PermyakovSergei E Permyakov
Jun 13, 2020·Human Vaccines & Immunotherapeutics·Anissa A WidjajaStuart A Cook
Sep 10, 2014·Acta Crystallographica. Section D, Biological Crystallography·Tracy L PutoczkiMichael D W Griffin
May 5, 2018·Nature Reviews. Drug Discovery·Christoph GarbersStefan Rose-John
Mar 11, 2018·The Journal of Biological Chemistry·Juliane Lokau, Christoph Garbers

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