Anti-Helicobacter pylori activity of non-living, heat-killed form of lactobacilli including Lactobacillus johnsonii No.1088

FEMS Microbiology Letters
Y AibaYasuhiko Komatsu

Abstract

Some strains of lactic acid bacteria are reported to inhibit the growth of Helicobacter pylori and proposed to be useful to support so-called triple therapy for H. pylori. Although most strains must be alive to exert their anti-H. pylori activity, some lactobacilli strains are effective even when dead. One possible underlying mechanism of such an activity of non-living lactobacilli is reportedly co-aggregation with H. pylori. In this study, we found that a non-living heat-killed form of Lactobacillus johnsonii No.1088 (HK-LJ88) and also that of some other lactobacilli inhibited the growth of H. pylori in vitro. Furthermore, the number of H. pylori in the infected stomach of germ-free mice was significantly decreased by the repeated oral administration of HK-LJ88. Observation by scanning electron microscopy revealed that no co-aggregation had occurred between H. pylori and HK-LJ88; instead, deformations of H. pylori (e.g. disappearance of spiral, bending of cell body, coccoid formation, degradations, etc.) appeared after incubation for 24 h with HK-LJ88. These results suggest that HK-LJ88 inhibited H. pylori activity probably not by co-aggregation but by some unknown mechanism involving HK-LJ88's cell surface molecules and that ...Continue Reading

References

Apr 15, 1985·The Medical Journal of Australia·B J MarshallR J Glancy
Sep 1, 1997·Infection and Immunity·J G KustersC M Vandenbroucke-Grauls
Feb 24, 2001·European Journal of Gastroenterology & Hepatology·C P FelleyP Michetti
May 1, 2001·The Journal of Antimicrobial Chemotherapy·I SakamotoY Koga

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Citations

Feb 13, 2020·International Journal of Molecular Sciences·Jianfu Ji, Hong Yang
May 28, 2019·International Journal of Molecular Sciences·Núria PiquéDavid Miñana-Galbis
Dec 29, 2020·Critical Reviews in Food Science and Nutrition·Amin AbbasiLeili Aghebati-Maleki
Mar 16, 2021·Critical Reviews in Food Science and Nutrition·Amin AbbasiNayyer Shahbazi
Jun 8, 2021·Journal of Agricultural and Food Chemistry·Qingqing ZhouQing Gu
Sep 2, 2021·Journal of Food Biochemistry·Somnath Basak, Jyoti Gokhale

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