Anti-hepatitis B core positivity as a risk factor for hepatocellular carcinoma in alcoholic cirrhosis: a case-control study

Alcohol
Oh Sang KwonYun Soo Kim

Abstract

Hepatocellular carcinoma (HCC) is occasionally developed in patients with alcoholic cirrhosis. Old age, male gender, lifetime quantity of alcohol, and presence of hepatitis C virus (HCV) infection are risk factors for HCC in alcoholic cirrhosis. In this study, we investigated whether anti-hepatitis B core (HBc) positivity or occult hepatitis B virus (HBV) infection is a risk factor for HCC in patients with alcoholic cirrhosis. Between January 2006 and August 2008, a total of 72 cirrhotic male patients with an initial diagnosis of HCC, hospitalized in three major hospitals in the Incheon area, were enrolled as cases. Another 72 cirrhotic male patients without HCC, who matched the cases by age (±3 years), were enrolled as controls. All cases and controls were negative for hepatitis B surface antigen and anti-HCV, but had history of chronic alcohol intake over 80 g per day. The clinical characteristics including presence of anti-HBc or serum HBV DNA (identified by nested polymerase chain reaction) were investigated. The mean age of both the cases and controls was 62 ± 10 years. The basal laboratory data, Child-Pugh scores, total lifetime alcohol intake (1459 ± 1364 versus 1641 ± 1045 kg), and detection rates of serum HBV DNA [31.7...Continue Reading

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Citations

Apr 23, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Man XieJidong Jia
Oct 1, 2013·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Jong Joon Lee, Oh Sang Kwon
Jul 5, 2016·Clinics in Liver Disease·Kartik JoshiRobert Gish
Feb 26, 2016·The Cochrane Database of Systematic Reviews·Omar M Abdel-Rahman, Zeinab Elsayed
Jan 25, 2020·The Cochrane Database of Systematic Reviews·Omar Abdel-Rahman, Zeinab Elsayed

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