Anti-hepatitis C virus activity and synergistic effect of Nymphaea alba extracts and bioactive constituents in liver infected cells

Microbial Pathogenesis
Sidra RehmanSheikh Riazuddin

Abstract

Without an effective vaccine, hepatitis C virus (HCV) remains a global threat, inflicting 170-300 million carriers worldwide at risk of cirrhosis and hepatocellular carcinoma (HCC). Though various direct acting antivirals have been redeemed the hepatitis C treatment, a few restraints persist including possible side effects, viral resistance emergence, excessive cost which restricts its availability to a common person. There is no preventive HCV vaccine available today so the discovery of potent antiviral natural flora and their bioactive constituents may help to develop preventive cures against HCV infection. In current study, we aim to clarify anti-HCV activity of methanol and acetone extracts along with the purified fractions of Pakistani local plant, Nymphaea alba L (N. alba) using Huh-7 cell line as transfection model. Synergistic study of purified fractions with interferon was performed using MDBK cell line (expressing interferon receptors) as transfection model. Recent study by our research group has observed potent anti-HCV NS3 protease activity of methanol and acetone extracts of N. alba. Effect of N. alba extracts, its fractions precisely, the N1 and N8 fractions on HCV replication was demonstrated by analyzing viral g...Continue Reading

Citations

Dec 28, 2019·Antibiotics·Mihaela CudalbeanuRodica Mihaela Dinica
Aug 23, 2020·Nutrients·Paolino NinfaliEmanuele Salvatore Scarpa
Feb 17, 2021·Phytotherapy Research : PTR·Sofi Imtiyaz AliShowkat Ul Nabi
May 6, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuzhen GaoYouming Zhang
Aug 10, 2021·Frontiers in Pharmacology·Wenkai YangJianguo Wu

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