Anti-HIV-1 activity of the Iboga alkaloid congener 18-methoxycoronaridine

Planta medica
Edinete M SilvaD C Bou-Habib

Abstract

The Iboga alkaloid congener 18-methoxycoronaridine (18-MC) exhibits in vitro leishmanicidal and in vivo anti-addiction properties. In this paper, we describe that 18-MC inhibits HIV-1 infection in human peripheral blood mononuclear cells (PBMCs) and monocyte-derived macrophages. We found that 18-MC inhibits the replication of primary isolates of HIV-1 in a dose-dependent manner, regardless of the preferential chemokine receptor usage of the isolates, at non-cell-toxic concentrations. The antiretroviral activity of 18-MC resulted in EC (50) values of 22.5 +/- 4.7 microM and 23 +/- 4.5 microM for R5 and X4 isolates, respectively, in PBMCs, and a therapeutic index (TI) of 14.5. Similar findings were observed for inhibition of HIV-1 replication in macrophages: EC (50) equal to 12.8 +/- 5 microM and 9.5 +/- 3 microM for an R5 virus after 14 and 21 days of infection, respectively, with TI equal to 25.6 and 34.5. 18-MC moderately inhibits the HIV-1 enzyme reverse transcriptase (IC (50) = 69.4 microM), which at least partially explains its antiretroviral activity.

Citations

Nov 22, 2007·Journal of Ethnopharmacology·Kenneth R AlperCharles D Kaplan
Feb 20, 2007·Parasitology International·Deivid Costa SoaresElvira Maria Saraiva
Mar 18, 2016·The American Journal of Bioethics : AJOB·Michael H AndreaeRosamond Rhodes
May 11, 2016·Organic Letters·Gaoyuan ZhaoXuegong She
Oct 27, 2010·Natural Product Reports·Inder Pal Singh, Hardik S Bodiwala
May 27, 2006·Revista de saúde pública·Francisco Inácio Bastos, Mariana A Hacker
Jun 26, 2021·European Journal of Medicinal Chemistry·Ojasvi GuptaVikramdeep Monga

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