Anti-HIV and antiplasmodial activity of original flavonoid derivatives

Bioorganic & Medicinal Chemistry
Gilles CasanoMaxime Robin

Abstract

In our search for potent anti-HIV and antiplasmodial agents, novel series of flavonoid derivatives and their chalcone intermediates were synthesized and evaluated for inhibition of HIV multiplication and antiproliferative activity on Plasmodium falciparum parasites. Chalcones exhibited a more selective antiplasmodial activity than flavonoids. Methoxyflavone 7e was the only one compound active in both P. falciparum and HIV-1 whereas aminomethoxyflavones showed activity against HIV-2. Para substitution on the B ring seemed to increase HIV-2 potency.

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Citations

Jul 16, 2013·European Journal of Medicinal Chemistry·Kapil JuvaleMichael Wiese
May 17, 2014·Biology·Jason DavenportRobert L Matts
Apr 3, 2014·European Journal of Medicinal Chemistry·Rangappa S KeriR Geetha Balakrishna
Jul 16, 2014·European Journal of Medicinal Chemistry·Manjinder SinghOm Silakari
Aug 10, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hongbin ChenZongping Zheng
Aug 24, 2019·Phytotherapy Research : PTR·Pone Kamdem Boniface, Elizabeth Igne Ferreira
Nov 25, 2020·Journal of Drug Targeting·Dana ElkhalifaAshraf Khalil
Aug 3, 2019·Bioorganic Chemistry·Man XuK P Rakesh
Jul 2, 2021·Advances in Virology·Maria S Serna-ArbeláezWildeman Zapata
May 11, 2017·Chemical Reviews·Chunlin ZhuangZhenyuan Miao

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