Anti-HIV potential of a new interferon, interferon-tau (trophoblastin).

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association
Nathalie Dereuddre-BosquetDominique Dormont

Abstract

Antiretroviral effects of a new class of interferon (IFN), IFN-tau, were compared with those of IFN-alpha in primary peripheral blood lymphocytes (PBLs) and monocyte-derived macrophages (MDMs), infected in vitro by human immunodeficiency viruses type 1, HIV-1/LAI, and HIV-1/DAS isolates, respectively. Cells were treated with recombinant IFN 24 h before or after HIV infection and then continuously exposed. Viral replication was monitored twice a week by quantifying the reverse transcriptase activity in cell culture supernatants. Integrated proviral DNA was monitored 24 h after infection in IFN-tau-pretreated MDMs, using specific gag gene amplification by the polymerase chain reaction. IFN-tau inhibited HIV-1 replication in both PBLs and MDMs as well as in peripheral blood mononuclear cells (PBMCs). IFN-tau was 35-fold more potent than IFN-alpha in PBLs and 100-fold more potent in MDMs. Differences were observed in the amount of integrated proviral DNA between untreated and 10 IU/ml IFN-tau-treated HIV-infected MDMs. IFN-tau exhibits significant anti-HIV activity in comparison to IFN-alpha, and like other IFNs, it seems to interact with several steps of HIV replication cycle.

References

May 1, 1979·Journal of Reproduction and Fertility·J MartalS Wintenberger-Torrès
Dec 1, 1991·Journal of Interferon Research·P M Pitha
Feb 1, 1990·Clinical Immunology and Immunopathology·R S KornbluthD D Richman
Aug 1, 1991·American Journal of Reproductive Immunology : AJRI·F W Bazer, H M Johnson
Apr 29, 1988·Biochemical and Biophysical Research Communications·C H PontzerH M Johnson
May 31, 1984·Biochemical and Biophysical Research Communications·M A ReyJ C Chermann
Sep 1, 1994·AIDS·H C Lane
Nov 1, 1993·Journal of Reproductive Immunology·A Assal-MelianiG Chaouat

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Citations

Aug 5, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·T M JohnsonN R Krishna
Oct 22, 1998·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·W TuoF W Bazer
Jan 1, 2009·Bioinformation·Vishawdeep Singh JamwalManmohan Singh Chauhan
Feb 1, 2017·Antiviral Research·Jayaramaiah UsharaniHyang-Sim Lee
Feb 6, 1998·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·A P AlexenkoR M Roberts
Dec 1, 2009·Viruses·Esperanza Gómez-LucíaAna Doménech
May 29, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H T KimT L Ott
Nov 11, 1998·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·R M RobertsJ Bixby
Aug 20, 2005·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Christine Rogez-KreuzPascal Clayette
Nov 17, 2001·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·D K TennakoonC J Welsh
Jan 19, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·A P AlexenkoR M Roberts
Feb 12, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·A de la Concha-BermejilloF W Bazer
Oct 14, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·A P AlexenkoR M Roberts
Jun 25, 2005·International Immunology·Christine Rogez-KreuzPascal Clayette
Jan 25, 2000·The Journal of General Virology·R A JusteA de La Concha-Bermejillo

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