Anti-HPV-E7 seropositivity and risk of esophageal squamous cell carcinoma in a high-risk population in China

Carcinogenesis
Zhonghu HeYang Ke

Abstract

Results of previous serologic studies on the association of human papillomavirus (HPV) with esophageal squamous cell carcinoma (ESCC) have been inconsistent. From 2007 to 2010, the authors collected blood samples and relevant demographic data from 1435 patients with ESCC and 2071 age- and sex-matched normal controls from Anyang, China. HPV-16, 18 and 57 E7 antibodies were evaluated with the glutathione-S-transferase capture ELISA. The proportions of subjects who were positive for antibodies against these three HPV antigens in the case group were all significantly higher than those in the control group. In multivariate analysis, the presence of HPV-16 E7 antibody was associated with an increased risk of ESCC [odds ratio (OR) = 3.6, 95% confidence interval (CI): 2.5-5.0], whereas the presence of HPV-18 (OR = 1.1, 95% CI: 0.7-1.7) and HPV-57 (OR = 1.3, 95% CI: 0.9-1.9) antibodies were not significant after adjustment for HPV-16. In multiple cutoff value analysis, the lowest OR for HPV-16 was obtained with the standard cut point mean + 3 SD. This study provides serological evidence in support of HPV-16 infection playing a role in the occurrence of ESCC in a high-incidence area of China.

References

Oct 1, 1981·Gynecologic Oncology·H zur HausenL Gissmann
Jan 1, 1994·Current Topics in Microbiology and Immunology·H zur Hausen
Oct 2, 2002·Journal of Clinical Pathology·K J Syrjänen
Oct 9, 2002·Journal of Virological Methods·Peter SehrMichael Pawlita
Sep 30, 2004·International Journal of Cancer. Journal International Du Cancer·Gina D TranPhilip R Taylor
Mar 1, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Aimee R KreimerSilvia Franceschi
Feb 24, 2006·International Journal of Cancer. Journal International Du Cancer·Farin KamangarSteven D Mark
Nov 30, 2006·International Journal of Cancer. Journal International Du Cancer·Elaine M SmithEva Hamsikova
May 15, 2007·The New England Journal of Medicine·Gypsyamber D'SouzaMaura L Gillison
Sep 11, 2007·Lancet·Mark SchiffmanSholom Wacholder
May 15, 2008·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·C GholipourM Abbasi
Nov 18, 2009·International Journal of Cancer. Journal International Du Cancer·Jill KoshiolSanford M Dawsey
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Jan 10, 2012·Journal of the National Cancer Institute·Freddy SitasUNKNOWN InterSCOPE Collaboration
Feb 18, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Fangcen GuoYang Ke

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Citations

Jan 24, 2016·Chinese Journal of Cancer·Ying ShiYa Cao
Dec 3, 2014·International Journal of Hygiene and Environmental Health·W R TangW W Au
Sep 28, 2016·World Journal of Gastroenterology : WJG·Dania BucchiGiuseppe Masanotti
Oct 16, 2019·Oncology Letters·Qian WuZhifeng Ning
May 29, 2020·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Carolyn Chang, Stephanie G Worrell
Jun 12, 2018·Analytical Cellular Pathology (Amsterdam)·Cailing JiangYuxian Bai

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