Anti-Hsp90 therapy in autoimmune and inflammatory diseases: a review of preclinical studies

Cell Stress & Chaperones
Stefan Tukaj, Grzegorz Węgrzyn

Abstract

Heat shock protein 90 (Hsp90), a 90-kDa molecular chaperone, is responsible for biological activities of key signaling molecules (clients) such as protein kinases, ubiquitin ligases, steroid receptors, cell cycle regulators, and transcription factors regulating various cellular processes, including growth, survival, differentiation, and apoptosis. Because Hsp90 is also involved in stabilization of oncogenic 'client' proteins, its specific chaperone activity blockers are currently being tested as anticancer agents in advanced clinical trials. Recent in vitro and in vivo studies have shown that Hsp90 is also involved in activation of innate and adaptive cells of the immune system. For these reasons, pharmacological inhibition of Hsp90 has been evaluated in murine models of autoimmune and inflammatory diseases. This mini-review summarizes current knowledge of the effects of Hsp90 inhibitors on autoimmune and inflammatory diseases' features and is based solely on preclinical studies.

References

Mar 20, 1987·Journal of Molecular Biology·P K Sorger, H R Pelham
Feb 1, 2000·The Journal of Biological Chemistry·S J FeltsD O Toft
Aug 4, 2001·The New England Journal of Medicine·A Davidson, B Diamond
Mar 27, 2002·Nature Reviews. Immunology·Pramod Srivastava
May 16, 2003·Nature·Gary S Firestein
Aug 21, 2003·Lancet·A Graham Pockley
Apr 2, 2005·Nature Reviews. Immunology·Willem van EdenBerent Prakken
Sep 22, 2005·Nature Reviews. Cancer·Luke Whitesell, Susan L Lindquist
Apr 3, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Vassiliki PoulakiJoan W Miller
Jul 7, 2007·American Journal of Respiratory and Critical Care Medicine·Anuran ChatterjeeJohn D Catravas
Aug 19, 2007·Immunologic Research·Seetha Monrad, Mariana J Kaplan
Jul 30, 2008·Cell Stress & Chaperones·Harm H KampingaLawrence E Hightower
Dec 23, 2009·Current Drug Discovery Technologies·Michael Kasperkiewicz, Enno Schmidt
Jul 24, 2010·Nature Reviews. Cancer·Jane TrepelLen Neckers
Dec 7, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Theodore J YunMarilyn R Kehry
Mar 5, 2011·British Journal of Pharmacology·Cris S ConstantinescuBruno Gran
Mar 16, 2011·Journal of Biomedicine & Biotechnology·Daniel PerryLaurence Morel
May 25, 2011·Dermatologic Clinics·Ralf J Ludwig, Detlef Zillikens
Aug 23, 2011·Biochimica Et Biophysica Acta·Mehdi Mollapour, Len Neckers
May 1, 2012·Cellular & Molecular Immunology·Samuel K ShimpChristopher M Reilly
May 9, 2012·Frontiers in Immunology·Thiago J BorgesWillem van Eden
Jan 8, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jooeun BaeNikhil C Munshi
Mar 1, 2013·International Review of Cell and Molecular Biology·Wei LiDavid T Woodley
Apr 6, 2013·BMC Medicine·Ziv RosmanGisele Zandman-Goddard
Jun 29, 2013·Biomedical Journal·Jing Li, Johannes Buchner
Jul 31, 2013·The Lancet Oncology·Rocio Garcia-CarboneroLuis Paz-Ares
May 7, 2014·Cell Stress & Chaperones·Stefan TukajMichael Kasperkiewicz
Jun 26, 2014·Experimental Dermatology·Stefan TukajMichael Kasperkiewicz
Jul 15, 2015·Bioorganic & Medicinal Chemistry Letters·Jeanette R McConnellShelli R McAlpine

❮ Previous
Next ❯

Citations

Oct 26, 2016·The Journal of Steroid Biochemistry and Molecular Biology·Stefan TukajMichael Kasperkiewicz
Sep 24, 2016·The Journal of Investigative Dermatology·Stefan TukajMichael Kasperkiewicz
Jan 10, 2019·Scandinavian Journal of Gastroenterology·Tore GrimstadRoald Omdal
Nov 23, 2018·Cell Stress & Chaperones·Jagoda MantejStefan Tukaj
Sep 30, 2020·Expert Opinion on Therapeutic Patents·Li LiXiao-Li Xu
Apr 3, 2020·Archivum Immunologiae Et Therapiae Experimentalis·Aleksandra Damasiewicz-BodzekKrystyna Tyrpień-Golder
Jul 30, 2020·International Journal of Molecular Sciences·Stefan Tukaj
Jul 30, 2020·International Journal of Molecular Sciences·Ruben Manuel Luciano Colunga BiancatelliJohn D Catravas
Sep 20, 2019·International Journal of Molecular Sciences·Eman A TahaTakanori Eguchi
May 3, 2020·Cell Stress & Chaperones·Stefan TukajKrzysztof Sitko
May 11, 2019·Cell Stress & Chaperones·Stefan Tukaj, Maciej Kaminski
Jun 5, 2020·The Biochemical Journal·Zhou ZhouMingui Fu
Jan 1, 2019·Synthetic Communications·Jatinder KaurBrian S J Blagg
Dec 10, 2020·International Journal of Molecular Sciences·Abdul Q KhanShahab Uddin
Feb 29, 2020·Ageing Research Reviews·Marta Gonzalez-FreireRafael de Cabo
Dec 15, 2019·Cellular Signalling·Khadeja-Tul KubraNektarios Barabutis
Apr 6, 2021·Mechanisms of Ageing and Development·Nektarios BarabutisMohammad A Uddin
Nov 7, 2021·Experimental Dermatology·Stefan TukajMichael Kasperkiewicz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Ai zheng = Aizheng = Chinese journal of cancer
Yi Chen, Jian Ding
Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte
A E KabakovVladimir L Gabai
© 2022 Meta ULC. All rights reserved