Anti-Hu-associated paraneoplastic limbic encephalitis presenting as rapidly progressive non-convulsive status epilepticus

Journal of the Neurological Sciences
Alberto J EspayGünseli Sarpel

Abstract

We report a 68-year-old woman who developed refractory non-convulsive generalized status epilepticus secondary to anti-Hu antibodies, detected by immunofluorescence and confirmed by Western immunoblotting. The patient presented with rapidly evolving impairment in consciousness and electroencephalographic evidence of lateralized pseudoperiodic sharp-wave discharges. Ataxia and sensory neuropathy developed within the first two weeks. To our knowledge, this is the first description of a very rapidly progressive non-convulsive status epilepticus of paraneoplastic origin. Serum anti-Hu antibodies deserve to be considered among the investigations required in the evaluation of rapidly progressive epileptic syndromes even when little or no imaging abnormalities are found.

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Citations

Mar 14, 2009·The Neurologist·Vicente VillanuevaEloy Elices
May 18, 2011·Current Opinion in Pulmonary Medicine·Sai-Ching J YeungSonali N Thosani
Oct 3, 2013·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Peter W Kaplan, Raoul Sutter
Oct 2, 2008·Journal of Neurosurgery·Tracy WeimerAdriana Palade
Aug 21, 2007·Clinical Neurology and Neurosurgery·Rishi V A Sheorajpanday, Peter P De Deyn
Apr 29, 2006·Journal of the Neurological Sciences·John E Greenlee
Jul 4, 2013·Clinical EEG and Neuroscience·Ugur CikrikçiliHakan Gürvit
Nov 10, 2007·Current Opinion in Neurology·Francesc Graus, Josep Dalmau
Dec 11, 2017·Internal Medicine Journal·Zara A IoannidesRobert D Henderson
Apr 3, 2018·The Journal of Obstetrics and Gynaecology Research·Kyong Jin Shin, Yong Il Ji
Sep 15, 2019·Autoimmunity Reviews·Valerio FrazziniVincent Navarro

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