PMID: 7536411Apr 1, 1995Paper

Anti-(human immunodeficiency virus) activity of polyoxotungstates and their inhibition of human immunodeficiency virus reverse transcriptase

The Biochemical Journal
P S MooreA J Hay

Abstract

Heteropolyoxotungstates of the Keggin class containing different heteroatoms were tested for inhibition of two strains of human immunodeficiency virus 1 (HIV-1); they exhibited varying antiviral activity. Compounds containing boron were inactive, only one of those containing phosphorus showed selective anti-viral activity, whereas all silicon-containing compounds exhibited significant anti-viral activity in C8166 cells infected with the IIIB strain. Their effectiveness was some 10-fold higher in JM cells with selectivity indices of about 2000. The silicotungstates were effective inhibitors of HIV reverse transcriptase, showing greater inhibition with RNA/DNA template primers than with DNA/DNA template.primer. Kinetic analysis demonstrated that they inhibit the enzyme by different mechanisms, as, of the four compounds examined, two competed with template.primer and two competed with deoxynucleoside triphosphate. Inhibition of DNA polymerase activity by these compounds was compared using polymerases from different sources, including human; although not necessarily most specific for HIV-1 reverse transcriptase, they did not inhibit all DNA polymerases to a similar degree.

Citations

Oct 23, 2010·Ecotoxicology and Environmental Safety·Nikolay Strigul
May 3, 2008·Chemico-biological Interactions·Hassan H HammudJulnar Usta
Jul 31, 2008·Journal of Enzyme Inhibition and Medicinal Chemistry·Pankaj HazarikaNashreen S Islam
Jul 27, 2006·International Journal of Hematology·Andrew M L Lever, Kuan-Teh Jeang
Dec 26, 2001·Chemical Reviews·A Y Louie, T J Meade

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