Anti-hyperalgesic effect of Lippia grata leaf essential oil complexed with β-cyclodextrin in a chronic musculoskeletal pain animal model: Complemented with a molecular docking and antioxidant screening

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Pollyana S Siqueira-LimaJullyana S S Quintans

Abstract

Due to its unclear pathophysiology, the pharmacological treatment of fibromyalgia is a challenge for researchers. Studies using medicinal plants, such as those from the genus Lippia, complexed with cyclodextrins (CDs) have shown innovative results. The present research intended to evaluate the effect of an inclusion complex containing β-cyclodextrin (βCD) inclusion complex with Lippia grata (LG) essential oil in a chronic musculoskeletal pain model, its central activity and its possible interaction with neurotransmitters involved in pain. After acid saline-induced chronic muscle pain, male mice were evaluated for primary and secondary hyperalgesia and muscle strength. Moreover, an antagonist assay was performed to assess the possible involvement of the opioidergic, serotonergic and noradrenergic pathways. In addition, Fos protein in the spinal cord was assessed, and a docking study and antioxidant assays were performed. The treatment with LG-βCD, especially in the dose of 24mg/kg, was able to significantly decrease (p<0.05) the paw withdrawal and muscle threshold. Furthermore, LG-βCD was shown to affect the opioidergic and serotonergic pathways. There were no significant changes in muscle strength. Fos protein immunofluorescenc...Continue Reading

Citations

Dec 21, 2019·Current Protein & Peptide Science·Luciana Scotti, Marcus T Scotti
Jun 4, 2020·Biology·Anita Oliveira Brito Pereira Bezerra MartinsIrwin Rose Alencar de Menezes
Jun 18, 2020·Frontiers in Pharmacology·Davidson Barbosa AssisReinaldo Nóbrega de Almeida
Dec 6, 2019·Peptides·Richard J Bodnar
Feb 14, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Thais B AlbertiMarcelo Maraschin
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Aswir Abd RashedDevi Nair Gunasegavan Rathi
Jul 16, 2021·Pharmacology & Therapeutics·Evelyne Silva BrumSara Marchesan Oliveira
Nov 28, 2018·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jose I A Beserra-FilhoAlessandra M Ribeiro
Nov 7, 2019·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Allan John de Oliveira MeloMarcelo Cavalcante Duarte

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