Anti-hypersensitivity effects of Shu-jing-huo-xue-tang, a Chinese herbal medicine, in CCI-neuropathic rats

Journal of Ethnopharmacology
Haihua ShuKazuo Hanaoka

Abstract

Shu-jing-huo-xue-tang (SJHXT) (Japanese name: Sokei-kakketu-to), a traditional Chinese herbal medicine composed of 17 crude drugs, has been prescribed over hundreds of years for treatment of chronic pain syndromes. We evaluated if oral SJHXT could suppress neuropathic pain behaviors in rats with chronic constriction injury (CCI) of the sciatic nerve. (1) Rats received repeated oral SJHXT 0.5 or 1.0 g/kg once daily for 14 days starting 24 h after CCI surgery, while neuropathic manifestations were evaluated until day 20 post-CCI. (2) Other groups of rats received single oral SJHXT 1.0 g/kg on day 14 post-CCI. (3) Additional groups of rats received oral SJHXT 1.0 g/kg on day 14 post-CCI, concomitantly with intraperitoneal yohimbine 1 mg/kg or methysergide 5 mg/kg. Neuropathic manifestations, including mechanical allodynia and thermal hyperalgesia, were evaluated with paw withdrawal responses to increasing mechanical pressure and radiant heat, respectively. Mechanical allodynia and thermal hyperalgesia developed by day 14 post-CCI. Repeated oral SJHXT for 14 days produced anti-allodynic and anti-hyperalgesic effects that outlasted the period of drug administration. Single oral SJHXT on day 14 also produced significant anti-allodyni...Continue Reading

References

Jan 1, 1994·The American Journal of Chinese Medicine·T IsonoY Omiya
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Mar 3, 2004·The American Journal of Chinese Medicine·Shigeyuki KanaiHideaki Higashino
Sep 27, 2005·Journal of Ethnopharmacology·Hongmeng XuKazuo Hanaoka
Sep 30, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·E Alfonso Romero-SandovalJames C Eisenach
Nov 30, 2005·Journal of Pharmacological Sciences·Yuji OmiyaShuichi Takeda
Apr 5, 2008·The Journal of Pain : Official Journal of the American Pain Society·Xiao-Jun ZhangZhao-Xiang Bian
Sep 10, 2008·Pharmacology, Biochemistry, and Behavior·Francisco de Sousa Nogueira-NetoYara Cury

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Citations

Apr 13, 2013·Journal of Ethnopharmacology·Florence Tsofack NgueguimNaibedya Chattopadhyay

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