Anti-hypertensive and cardioprotective effects of a novel apitherapy formulation via upregulation of peroxisome proliferator-activated receptor-α and -γ in spontaneous hypertensive rats

Saudi Journal of Biological Sciences
Yanru SunXiaoqing Miao

Abstract

Ventricular remodeling is associated with many heart diseases, and ventricular remodeling induced by hypertension can be fatal independent of hypertension. In this study, we prepared a novel apitherapy formulation, designated Bao-Yuan-Ling (BYL), which contained propolis, royal jelly, and bee venom, to treat spontaneous hypertensive rats (SHRs). We then evaluated the pharmacology of BYL and the potential mechanisms through which BYL affects hypertension and ventricular remodeling. We found that BYL treatment could reduce blood pressure in SHRs. Thereafter, we found that BYL treatment reduced serum levels of angiotensin II, endothelin 1, and transforming growth factor-β and improved the myocardial structure. Moreover, the results of quantitative real-time polymerase chain reaction indicated that BYL treatment could upregulate the mRNA expression of peroxisome proliferator-activated receptor (PPAR)-α and PPAR-γ. Thus, we could conclude that BYL had hypotensive and cardioprotective effects in SHRs, potentially through improvement of myocardial energy metabolism.

Citations

Dec 2, 2019·Biological Trace Element Research·Milad AshrafizadehSaeed Samarghandian
Apr 11, 2019·Scientific Reports·Rafa S AlmeerAhmed E Abdel Moneim
Dec 29, 2020·Frontiers in Public Health·Keneth Iceland KasoziSusan Christina Welburn
Jan 8, 2021·Biology·Henrique SilvaAntónio Raposo
Sep 23, 2021·Experimental Biology and Medicine·Faten ZahranNabila Zein

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Methods Mentioned

BETA
enzyme-linked immunosorbent assays
PCR

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