Anti-Hypertensive Effects of Acacia Polyphenol in Spontaneously Hypertensive Rats

International Journal of Molecular Sciences
Nobutomo IkarashiKiyoshi Sugiyama

Abstract

We have previously demonstrated that acacia polyphenol (AP) exerts strong anti-obesity, anti-diabetic, and anti-atopic dermatitis effects. In the present study, we investigated the anti-hypertensive effects of AP. Spontaneously hypertensive rats (SHR) with hypertension and control Wistar Kyoto rats (WKY) were used. WKY and SHR were fed AP-containing food or AP-free food (control group) ad libitum for 4 weeks, and their blood pressures were measured. After AP administration, both systolic and diastolic blood pressures were significantly lower in the SHR group than in the control group. There were no differences in the systolic or diastolic blood pressure of WKY between the AP group and the control group. Angiotensin-converting enzyme (ACE) activity, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase expression, and superoxide dismutase (SOD) activity in SHR kidneys were not altered by AP administration. Blood SOD activity in SHR was significantly higher in the AP group than in the control group. AP exerts anti-hypertensive effects on hypertension but has almost no effect on normal blood pressure. The anti-hypertensive effects of AP may be related to the anti-oxidative effects of increased blood SOD activity.

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Citations

Apr 6, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sosuke Ogawa, Yoshikazu Yazaki
Jul 28, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fu WangYouping Liu
Jan 18, 2020·Food Science of Animal Resources·Da-Eon LeeKyoung-Sik Han
Aug 30, 2020·International Journal of Molecular Sciences·Daniel A Jacobo-Velázquez, Luis Cisneros-Zevallos
Dec 28, 2019·Endocrine, Metabolic & Immune Disorders Drug Targets·Mohammed Ajebli, Mohamed Eddouks
Nov 13, 2020·Journal of Agricultural and Food Chemistry·Xiaocao LiuBradley W Bolling

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