Anti-hypertensive effects of the methanol/methylene chloride stem bark extract of Mammea africana in l-NAME-induced hypertensive rats

Journal of Ethnopharmacology
P E Nguelefack-MbuyoA Ziyyat

Abstract

The methanol/methylene chloride (CH(3)OH/CH(2)Cl(2)) extract from the stem bark of Mammea africana was showed to possess vasodilating effect in the presence and the absence of N(omega)-nitro-l-arginine methyl ester (l-NAME). The present study was designed to evaluate the effects of the methanol/methylene chloride from the stem bark of Mammea africana. The extract (200 mg/(kg day)) was administered orally in rats treated concurrently with l-NAME (40 mg/(kg day)). l-Arginine (100 mg/(kg day)) and captopril (20 mg/(kg day))were used as positive controls. Bodyweight, systolic arterial blood pressure and heart rate were measured weekly throughout the experiment period (28 days). At the end of treatment, animals were killed and the cardiac mass index evaluated. The aorta was used to evaluate the endothelium-dependant relaxation to carbachol. The aorta contraction induced by noradrenalin was also examined and expressed as a percentage of that induced by KCl. The extract neither affected the body weight nor the heart rate. The extract as captopril completely prevented the development of arterial hypertension. Both the substances failed to restore the endothelium-dependent vascular relaxation and increased the vascular contraction to no...Continue Reading

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Citations

Oct 20, 2012·Naunyn-Schmiedeberg's Archives of Pharmacology·Subramanian KumarBoobalan Raja
Nov 16, 2011·Journal of Medicinal Food·Aliaa E M K El-MosallamySanaa A Kenawy
Oct 12, 2010·Indian Journal of Pharmacology·Elvine Pami Nguelefack-MbuyoAlbert Kamanyi
Apr 16, 2013·BioMed Research International·K N VenugopalaB Odhav
Sep 26, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Elvine Pami Nguelefack-MbuyoThéophile Dimo
Nov 28, 2014·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Byeong Hyeok YeChi Dae Kim
Nov 12, 2020·Natural Products and Bioprospecting·Tarawanti VermaNagendra Singh Chauhan

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