Anti-hyperuricemic and nephroprotective effects of rhein in hyperuricemic mice

Planta medica
Zhaoqing MengZhonglin Yang

Abstract

Hyperuricemia has been considered to be a key risk factor for kidney disease. The formation of uric acid crystals in the kidney further stimulates an intensive inflammatory response. Rhein possesses various pharmacological activities, including anti-inflammatory, antioxidative, antitumor, purgative effects, and so on. To our knowledge, no previous work has been reported about the therapeutic effect of rhein on urate nephropathy. In this study, a model of hyperuricemia and nephropathy induced by adenine and ethambutol in mice was established. Meanwhile, the potential beneficial effects and mechanisms of rhein on hyperuricemia and nephropathy were also investigated. The results demonstrated that rhein significantly decreased the serum uric acid level by inhibiting the xanthine oxidase activity and increasing the excretion of urinary uric acid. In addition, rhein also markedly improved kidney damage related to hyperuricemia. Further investigation indicated that rhein improved the symptoms of nephropathy through decreasing the production of proinflammatory cytokines, including interleukin 1β, prostaglandin E2, and tumor necrosis factor-α and inhibiting the expression of transforming growth factor-β1. The present study suggests that...Continue Reading

Citations

Feb 24, 2016·Journal of Toxicology·Marwa M M RefaieAly M Abdelrahman
Sep 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nomadlozi Blessings HlopheRebamang Anthony Mosa
Dec 30, 2017·Experimental and Therapeutic Medicine·Ya-Jun LinGang Hu
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Apr 16, 2021·Frontiers in Pharmacology·Mingming ZhaoYu Zhang
Aug 31, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Gang-Min LiCheng Peng

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